Results 81 to 90 of about 2,921,382 (257)

Acquisition of educational values at the Real Madrid Foundation’s social-sports schools

Frontiers in Psychology
The objective of this study was to analyse the impact of the educational programme of the Real Madrid Foundation (RMF) on the acquisition of educational values at social-sports football and basketball schools among children aged between 12 and 16 years ...
Gema Ortega-Vila, Enrique Ortega-Toro, Enrique Ortega-Toro, Francisco Javier Giménez-Fuentes-Guerra, Francisco Javier Giménez-Fuentes-Guerra, José Robles-Rodríguez, Francisco Alarcón-López, Francisco Alarcón-López, Manuel Tomás Abad-Robles, Manuel Tomás Abad-Robles   +9 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Enhancing soccer goalkeepers penalty dive kinematics with instructional video and laterality insights in field conditions

Scientific Reports
This study aimed to analyze the effect of laterality and instructional video on the soccer goalkeepers’ dive kinematics in penalty. Eight goalkeepers from youth categories (U15, U17, U20) were randomly divided into control (CG) and video instruction ...
Rafael Luiz Martins Monteiro, Carlos Cesar Arruda dos Santos, Patrick Blauberger, Daniel Link, Tiago Guedes Russomanno, Ariany Klein Tahara, Abel Gonçalves Chinaglia, Paulo Roberto Pereira Santiago   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A Tactical Games Model lesson plan to teach net games skills in elementary school

Formazione & Insegnamento
The study aimed to assess the efficacy of two physical education approaches, Traditional Teaching (TT) and Tactical Games Model (TGM), on some fourth-grade classes over a 13-weeks period.
Antonella Quinto, Teresa Iona, Michele Barca, Francesco Sgrò   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Active cooling device: A flexible, lab-scale experimental unit to develop spatio-temporal temperature control strategies

HardwareX
This work proposes an experimental unit that realizes a multi-input, multi-output manifold thermal management technology. The proposed setup is designed for experiments aimed at controlling spatiotemporal temperature distribution.
Victor Oliveira Ferreira, Wiebke Mainville, Vincent Raymond, Jean-Michel Lamarre, Antoine Hamel, Mikael Vaillant, Moncef Chioua, Bruno Blais   +7 more
doaj   +1 more source