Results 121 to 130 of about 2,277,854 (259)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Controllable Ratio of the Polyaniline-Needle-Shaped Manganese Dioxide for the High-Performance Supercapacitor Application. [PDF]

Nanomaterials (Basel), 2022
Aleithan SH, Ansari SA, Perdana MY, Alam K, Alhashim Z, Al-Amer K.   +5 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Automatic Performance Baselining of Kubernetes Microservices

reservedWhen making any change to the IT stack, like deploying a new application release, we must be able to understand its impact on application performance.
PALLANTE, LAURA
core  

Optimal Performance and Application for Seagull Optimization Algorithm Using a Hybrid Strategy. [PDF]

Entropy (Basel), 2022
Xia Q, Ding Y, Zhang R, Zhang H, Li S, Li X.   +5 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Federated semi-supervised learning based on feature alignment and knowledge distillation

Frontiers in Physics
IntroductionRecently, federated learning has been successfully applied in fields related to cyber-physical-social systems (CPSSs), owing to its ability to harness decentralized clients for training a global model while ensuring data privacy. The existing
Zhe Ding, Zhe Ding, Hao Yi, Hao Yi, Wenrui Xie, Wenrui Xie, Yuxuan Xiao, Qixu Wang, Qixu Wang, Qing Chen, Zhiguang Qin, Dajiang Chen   +11 more
doaj   +1 more source

Fabrication, Structure, Performance, and Application of Graphene-Based Composite Aerogel. [PDF]

Materials (Basel), 2021
Wei D, Liu X, Lv S, Liu L, Wu L, Li Z, Hou Y.   +6 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Poly(carbazole-co-1,4-dimethoxybenzene): Synthesis, Electrochemiluminescence Performance, and Application in Detection of Fe³. [PDF]

Polymers (Basel), 2022
Hou P, Zhang X, Lu Q, Chen S, Liu Q, Qiao C, Zhao H.   +6 more
europepmc   +1 more source