‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Correction: Facile preparation of a polypyrrole modified Chinese yam peel-based adsorbent: characterization, performance, and application in removal of Congo red dye. [PDF]
Wang Y +5 more
europepmc +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
2-Dimensional layered molybdenum disulfide nanosheets and CTAB-assisted molybdenum disulfide nanoflower for high performance supercapacitor application. [PDF]
Ganesha H +6 more
europepmc +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Active Electromagnetically Induced Transparency Effect in Graphene-Dielectric Hybrid Metamaterial and Its High-Performance Sensor Application. [PDF]
Gao F +7 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
[[abstract]]"The purpose of this research was to explore possible relationship between the application of E-commerce and the organizational performance in the Taiwanese professional sports event promotion organizations. The hypothesis for this research
陳朝鍵;Chen, Chao-Chien
core
Electrodeposition of CoxNiVyOz Ternary Nanopetals on Bare and rGO-Coated Nickel Foam for High-Performance Supercapacitor Application. [PDF]
Seyed-Talebi SM +4 more
europepmc +1 more source

