Results 121 to 130 of about 498,761 (251)

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

New frontiers in music education through the IEEE 1599 standard

open access: yes, 2012
IEEE 1599 is an international standard conceived for a comprehensive description of music. Inside a unique XML document, all the data and meta-data related to a single music piece can be coded, ranging from catalogue to structural, from notational to ...
A. Baratè, L.A. Ludovico
core   +1 more source

Modelling of a standard gas mixtures generator with computational fluid dynamics [PDF]

open access: yes, 2015
Monitoring VOC for climate change and for indoor and outdoor air quality at trace level concentrations need reference standard materials at high metrological performance.
Lecuna Maricarmen   +3 more
core  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Analaysis on Residual Network Models for Image Description Generation

open access: yes, 2019
This paper presents different deep learning models for generating the natural language description of the image. Moreover, we discussed how the deep learning model, which works for the natural language description of an image, can be implemented.
Phyu Phyu Khaing   +2 more
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Advanced performance simulation of gas turbine components and fluid thermodynamic properties [PDF]

open access: yes, 2008
The VIVACE European Cycle Program (“VIVACE-ECP”) was part of the virtual engine sub-project of VIVACE and was worth 6.63 million Euros. The main outcome of the “VIVACE-ECP” was the development of a cost effective gas turbine simulation environment ...
Sethi, Vishal
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Non-Standard Employment and Labour Force Participation: A Comparative View of the Recent Development in Europe [PDF]

open access: yes
This paper presents – in a new way of examination and portrayal – the extent and changes of nonstandard employment relationships (part-time work, fixed-term contracts, and self-employment) in 24 EU member states at two points of time, in 1998 and 2008 ...
Schmid, Günther
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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