Results 151 to 160 of about 452,974 (236)

MethyNano: supervised contrastive pretraining enables robust and generalizable methylation detection from nanopore sequencing. [PDF]

Bioinformatics
Yan J, Chen Y, Gong Y, Zhang C, Yang J.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Large language models approach clinician performance in ESC cardiovascular risk stratification: a vignette-based benchmark study. [PDF]

Eur Heart J Digit Health
Ferreira Santos J, de Brito Duarte R, Mota I, Santos RC, Moreira JM, Campos J, Silva NA, Neves B, Ladeiras-Lopes R, Leite F, Dores H.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A fusion-based multiomics classification approach for enhanced gene discovery in non-small cell lung cancer.

Bioinform Adv
Dwivedi K, Mahbod A, Ecker RC, Janjić K.   +3 more
europepmc   +1 more source

Quality metrics reflecting patient experience of gastrointestinal endoscopy in inflammatory bowel disease: results of national endoscopy dataset analysis. [PDF]

J Crohns Colitis
Jones F, Lavelle A, MacCarthy F, Patchett S, Morcos A, Moloney M, Cullen G, Slattery E, Leyden J, O'Morain C, Egan L, Zammarchi I, Iacucci M, Doherty GA.   +13 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Exploring the impact of specialist and generalist stars on organizational performance. [PDF]

PLoS One
Nalbantis G, Manger C, Pawlowski T, Yang P.   +3 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Benchmarking deep learning methods for Cα atom prediction in cryo-EM density maps. [PDF]

Bioinformatics
Zhang T, Liu Z, Ma Y, Feng C, Han R.
europepmc   +1 more source