Results 211 to 220 of about 455,500 (283)

Iterative Large Language Model-Guided Sampling and Expert-Annotated Benchmark Corpus for Harmful Suicide Content Detection: Development and Validation Study. [PDF]

JMIR Med Inform
Park K, Baik MJ, Hwang Y, Shin Y, Lee H, Lee R, Lee SM, Sun JYH, Lee AR, Yoon SY, Lee DH, Moon J, Bak J, Cho K, Paik JW, Park S.   +15 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

MateR: a novel genomic mating framework. [PDF]

Genetics
Fernández-González J, Metwally SM, Isidro Y Sánchez J.   +2 more
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

An Enhanced Event-Based Model for Integrated Flight Safety of Fixed-Wing UAVs. [PDF]

Sensors (Basel)
Ma X, Lu X, Li H, Lu X, Li J, Zhao J.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Addressing the need for economic modelling when designing and reporting a diagnostic testing accuracy study. [PDF]

Front Public Health
Xie X, Guo J, Holodinsky JK, Fu R.
europepmc   +1 more source

Identifying Adaptive Footprints in the Presence of Demographic Uncertainty. [PDF]

Genome Biol Evol
Arnab SP, Khan M, Campelo Dos Santos AL, Fumagalli M, DeGiorgio M.   +4 more
europepmc   +1 more source

Detection of sample swapping in anti-doping investigations using machine learning. [PDF]

Sci Rep
Rahman MR, Piper T, Thevis M, Maass W.
europepmc   +1 more source