Results 111 to 120 of about 69,653,451 (303)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Método para monitoramento do OEE em tempo real e a cadeia de ajuda como apoio a estratégia da manufatura enxuta [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2011O cenário altamente competitivo tem imposto novos padrões de desempenho, ao mercado, gerando para
Proença, Edgar Telles de
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Análise de desempenho de sistemas de produção modais de pecuária de cria no Brasil Performance evaluation of livestock production systems in Brazil

Production, 2013
Neste artigo propõe-se analisar comparativamente o desempenho de sistemas de produção modais de pecuária extensiva de corte na fase de cria em 21 municípios brasileiros.
João Carlos Correia Baptista Soares de Mello, Eliane Gonçalves Gomes, Urbano Gomes Pinto de Abreu, Thiago Bernardino de Carvalho, Sérgio de Zen   +4 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Logistics-production, logistics-marketing and external integration: Their impact on performance [PDF]

Highly competitive environments are leading companies to implement Supply Chain Management (SCM) to improve performance and gain a competitive advantage.
Cristina Giménez, Eva Ventura
core  

Efeito da utilização de simbiótico e do sistema de criação sobre o desempenho e morfometria do epitélio gastrintestinal de frangos de corte tipo colonial = Effect of symbiotic use and production system on the performance and morphometrics of the intestinal epithelium of free-range broiler chickens

Acta Scientiarum: Animal Sciences, 2007
O objetivo deste estudo foi avaliar o desempenho e a morfometria do epitélio intestinal de frangos de corte da linhagem colonial Label Rouge, submetidos a dietas com e sem adição de simbiótico, e distribuídos em dois sistemas de criação, confinados e com
Augusto Balog Neto, Ariel Antonio Mendes, Sabrina Endo Takahashi, Cristiane Sanfelice, Claudia Marie Komiyama, Rodrigo Garófallo Garcia   +5 more
doaj  

Capsicum annuum L.: Phenological and Yield Performance of Native and Commercial Genotypes Under Open-Field and Low-Technology Greenhouse Hydroponic Systems

Horticulturae
The performance of native landraces of Capsicum annuum L. under contrasting production systems remains poorly understood, limiting their evaluation under locally relevant production scenarios.
Brenda Nataly Hernández-Hernández, Adriana Delgado-Alvarado, Mario Alberto Tornero-Campante, Braulio Edgar Herrera-Cabrera, José Luis Jaramillo-Villanueva, Luz del Carmen Lagunes-Espinoza   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source