Results 201 to 210 of about 1,547,128 (294)

Horizon Scan of Emerging Issues at the Intersection of National Security, Artificial Intelligence, and Human Performance Enhancement. [PDF]

Sci Eng Ethics
Hereth B, de Boisboissel G, Bricknell MC, Brincker M, Casebeer W, Davidovic J, Davis J, Earl J, Eisikovits N, Feldman D, Garcia LF, Gilbert F, Guérin V, Henschke A, Hughes J, Lambert D, Latheef S, Moreno JD, Peebles IS, T Pham M, Pindyck S, Rudyak I, Shinomiya N, Shortland ND, Sparrow R, Stramondo J, Tabouy L, Tubig P, Whetham D, Evans NG.   +29 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Performance enhancement of a low-energy humidification dehumidification desalination system using the M-cycle. [PDF]

Sci Rep
Bakhtiari MA, Karimi MS, Firoozabadi B.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

From Pre-Swelling to Performance Enhancement: Mechanisms and Effects of an Instant Ultra High-Performance Bituminous Material Modifier. [PDF]

Materials (Basel)
Li Y, Ji H, Wang C, Zhang D, Wang F, Jiang G, Deng J, Ke J.   +7 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The post-activation performance enhancement effect of different plyometric training modalities on short-distance sprinting: An acute randomized crossover study. [PDF]

PLoS One
Qu W, Peng W, Li Y, Xie L, Sun J, Li D.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The critical role of isolated Ti³⁺ sites in MIL-125 for photocatalytic nitrate reduction: performance enhancement and deactivation mechanism. [PDF]

Chem Sci
Liao L, Zhao G, Shu R, Wang X, Zhang J, Yuan R.   +5 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source