Results 21 to 30 of about 1,554,477 (266)

Effect of the Similarity of Formulations and Excipients of Approved Generic Drug Products on In Vivo Bioequivalence for Putative Biopharmaceutics Classification System Class III Drugs

Pharmaceutics, 2023
One of the potential essential factors that restricts generic industry from applying the Biopharmaceutics Classification System (BCS) Class III biowaiver is adherence to the stringent formulation criteria for formulation qualitative (Q1) sameness and ...
Ping Ren, Theresa Chan, Wen-Cheng Yang, Mitchell Frost, Yan Wang, Markham Luke, Myong-Jin Kim, Robert Lionberger, Yi Zhang   +8 more
doaj   +1 more source

Assessing Readiness and Sustainability for Integrated Care in Ontario, Canada with the Integrated Care Leadership Survey

International Journal of Integrated Care
Introduction: Ontario, Canada, is shifting to a more integrated healthcare delivery system through the Ontario Health Team (OHT) initiative. The extent to which OHTs have the capabilities to engage in integrated care is unknown and important to designing
Ruth E. Hall, Kevin Walker, Nusrat S. Nessa, Walter P. Wodchis   +3 more
doaj   +1 more source

Blood Lactate and Maximal Lactate Accumulation Rate at Three Sprint Swimming Distances in Highly Trained and Elite Swimmers

Sports, 2023
We examined the blood lactate response, in terms of the maximal post-exercise concentration (Lamax), time to reach Lamax, and maximal lactate accumulation rate (VLamax), to swimming sprints of 25, 35, and 50 m.
Maria Mavroudi, Athanasios Kabasakalis, Anatoli Petridou, Vassilis Mougios   +3 more
doaj   +1 more source

Weekly External Load Correlation in Season Microcycles with Game Running Performance and Training Quantification in Elite Young Soccer Players

Sensors
The purpose of this study was to (a) correlate the weekly external training load with the game running performance in season microcycles and (b) specify the optimal training/game ratio of the weekly external load in elite youth soccer players.
Vasileios Kanaras, Yiannis Michailidis, Athanasios Mandroukas, Andreas Stafylidis, Lazaros Vardakis, Angelos E. Kyranoudis, Kosmas Christoulas, Ioannis Gissis, Thomas I. Metaxas   +8 more
doaj   +1 more source

Application of a Structured Training Plan on Different-Length Microcycles in Soccer—Internal and External Load Analysis between Training Weeks and Games

Applied Sciences, 2023
The aim of this study was to apply a training plan to four different-length microcycles (MIC) in soccer and analyze (a) the load within the training weeks and (b) the short-term effect on the matches that were played at the end of each microcycle.
Lazaros Vardakis, Yiannis Michailidis, Panagiotis Topalidis, Charalambos Zelenitsas, Athanasios Mandroukas, Ioannis Gissis, Kosmas Christoulas, George Mavrommatis, Thomas Metaxas   +8 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Differences in Physical Indexes between Football Players of Different Playing Positions and Correlation to the Weekly Training Load

Applied Sciences
The aim of this study was twofold: (a) to examine the differences on physical indexes between players of different playing positions and (b) to reveal the correlations between their physical parameters and the running profile within the weekly ...
Lazaros Vardakis, Marianthi Koutsokosta, Yiannis Michailidis, Athanasios Mandroukas, Andreas Stafylidis, Vasilis Kanaras, Charalampos Bamplekis, Andreas Fousekis, Konstantinos Stamatelos, Ioannis Metaxas, Charalambos Zelenitsas, Panagiotis Topalidis, Angelos E. Kyranoudis, Thomas I. Metaxas   +13 more
doaj   +1 more source

Performance evaluation for MOTIFSIM [PDF]

Biological Procedures Online, 2018
Previous studies show various results obtained from different motif finders for an identical dataset. This is largely due to the fact that these tools use different strategies and possess unique features for discovering the motifs. Hence, using multiple tools and methods has been suggested because the motifs commonly reported by them are more likely to
Tran, Ngoc Tam L., Huang, Chun-Hsi
openaire   +2 more sources

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source