Results 201 to 210 of about 1,152,645 (265)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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An Index of Hospital Performance
Medical Care, 1978The purpose of this paper is to describe a simple index for computing relative hospital performance. An analysis of 33 short-stay general hospitals in New South Wales was used to develop the index. The index is based on patterns of admissions for each hospital, adjusting the hospital's crude death rate for the age distribution of patients treated and ...
S J, Duckett, S M, Kristofferson
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Glycemic Index and Endurance Performance
International Journal of Sport Nutrition and Exercise Metabolism, 2010The aim of this review is to provide an up-to-date summary of the evidence surrounding glycemic index (GI) and endurance performance. Athletes are commonly instructed to consume low-GI (LGI) carbohydrate (CHO) before exercise, but this recommendation appears to be based on the results of only a few studies, whereas others have found that the GI of CHO ...
Carolyn M, Donaldson +2 more
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A performance index for semicoherent structures
Reliability Engineering & System Safety, 2004Abstract The index introduced here provides a normalized measure of the effectiveness of any semicoherent structure. We study the mathematical properties of the index and derive different axiomatic characterizations for it. Moreover, close relationships are shown to reliability functions and also to the Birnbaum structural importance measure—for ...
Francesc Carreras +2 more
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2012
Effectively creating indexes within your databases will single handedly provide the largest increase in application performance. Unfortunately, creating indexes incorrectly or without regard for the application’s behavior can actually hinder performance.
Ken Simmons, Sylvester Carstarphen
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Effectively creating indexes within your databases will single handedly provide the largest increase in application performance. Unfortunately, creating indexes incorrectly or without regard for the application’s behavior can actually hinder performance.
Ken Simmons, Sylvester Carstarphen
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Are 'Indexes' an Index of Physician Performance?
Archives of Internal Medicine, 1985In this issue of theArchives, Hansen and associates 1 present data from a chart audit reflecting physician behavior in the interpretation of RBC indexes. The authors begin with the fact that patients having low mean RBC volumes and high RBC counts relative to those volumes will commonly be found to have thalassemic syndromes if properly examined ...
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