Results 141 to 150 of about 15,255,554 (338)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
EconomiesReflecting the shift from purely quantitative economic growth to broader socio-environmental sustainability, this study proposes a framework for assessing sustainable development (SD) by integrating Maslow’s hierarchy of needs with Bossel’s ...
Panagiotis Panagiotopoulos +5 more
doaj +1 more source
A method for soil health assessment in the conversion to organic farming [PDF]
, 2002 This paper was presented at the UK Organic Research 2002 Conference of the Colloquium of Organic Researchers (COR). The regulation for the assessment of the conversion to organic farming establishes the use of soil/produce pollution and the type of ...
Garrido, Marisol +3 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Assessing Performance of Kerman Province`s Hospitals Using Pabon Lasso Diagram between 2008 and 2010
بیمارستان, 2014 Background: A method of performance assessment is required to improve Productivity and reduce hospital costs . Pabon Lasso diagram is known as a tool for performance assessment.
M Mehrolhasani +2 more
doaj
Assessment of School Effectiveness in Greece using Multilevel Models [PDF]
In recent years, a lot of attention has been given to the so-called “performance indicators”, which are primarily used for institutional comparisons. Education and health are the area in which these indicators are widely applied, serving the needs of ...
Kosmopoulou, Anna, Panaretos, John
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Lisbon Strategy Targets are presented and assessed as accordingly to the domains of the structural indicators, the common indicators created to measure the progress towards reaching these objectives: Economic performance; Employment; Research ...
Ivan Ungureanu, Clementina +1 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source