Results 171 to 180 of about 2,172,465 (273)

Crucial key performance indicators for hospital evaluation: A scoping review. [PDF]

J Educ Health Promot
Talebpour A, Sadeghi-Bazargani H, Janati A, Pashazadeh F, Gholizadeh M.   +4 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Hospital Performance Indicators in Provision of Perinatal Services: A Qualitative Study. [PDF]

J Family Reprod Health
Jabbari Bayrami H, Abdollahi Sabet S, Naseri A, Hosseini MS.   +3 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Selecting performance indicators for farms and ranches engaged in collaborative agroecosystem research. [PDF]

J Environ Qual
Donovan M, Spiegal S, Kaplan N, Archer D, Bean A, Beebout SEJ, Bestelmeyer BT, Clark P, DeLong A, Fortuna AM, Friedrichsen CN, Hoover DL, Huggins D, Kleinman PJA, McIntosh MM, Renschler CS, Ritten J, Smith DR, Webb NP, Wulfhorst JD.   +19 more
europepmc   +1 more source

Participation of students who were in receipt of Disabled Students’ Allowance (DSA) : all undergraduate students : 2016/17 [PDF]

, 2018

core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

KERMIT: Performance indicators in electronic patient reported outcome measures: a modified Delphi. [PDF]

J Patient Rep Outcomes
Hatton NL, Baxter M, Lewis S, Hall PS, Spencer K.   +4 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Adjusting key performance indicators in ART laboratories according to controlled ovarian stimulation protocol. [PDF]

Front Physiol
Chen W, Cheng S, Liu Y, Wu Z, Zhang F, Huang X, Yao G, Song W, Jin H.   +8 more
europepmc   +1 more source