FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Evaluation of the Effectiveness of Insurance Branches Using Data Envelopment Analysis (DEA) (Case study: Branches of Insurance Company in the Southern Provinces of Iran) [PDF]
مدیریت بهره وری, 2013 Evaluation of the effectiveness of organizations has always been the concern of researchers. Hence, over the years numerous techniques for doing this have been proposed and used.
Mahmood Dniyali dah hooz, Saede Ketabi
doaj
Die lewensvatbaarheid van boerbokboerdery: 'n Vergelykende gevallestudie
Journal of Economic and Financial Sciences, 2014 The aim of this study was to design a case study where a number of management accounting evaluation techniques, namely performance measurement (short-term focus), capital investment evaluation (long-term focus) and risk, have been identified to compare ...
Wilbrie Fourie +2 more
doaj +1 more source
Examination of the relationship between organizational learning and financial performance mediated by innovation process in the industrial companies in Golpayegan [PDF]
مدیریت بازرگانی, 2014 Although organizational learning is often known as a goal, in the view of many stakeholders, the final aim of many organizations is optimization of financial results such as productivity, and innovation is among various factors which optimizes the ...
Amir Khanlari, Rezvan Sabze Ali
doaj +1 more source
Contemporary performance measurement and management (PMM) in digital economies
, 2016 The rate of change in the world is increasing both in scope and magnitude by rapidly developing digital technologies. The challenging problem for performance measurement and management (PMM) in the digital era is twofold: firstly, the constant change in ...
S. Nudurupati +2 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
A call for conceptual clarity: a soft systems view of performance measurement in public service delivery [PDF]
, 2005 Performance measurement systems and the publication of performance data are fundamental to the New Public Management, with its emphasis on decentralised service provision through a variety of agencies.
Pidd, M
core
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
On the Measurement of Business Performance in Strategy Research: A Comparison of Approaches
, 2015 A two-dimensional classificatory scheme highlighting ten different approaches to the measurement of business performance in strategy research is developed.
N. Venkatraman, V. Ramanujam
semanticscholar +1 more source