Results 101 to 110 of about 1,214,931 (316)

Enhancing climate change planning and adaptive management in marine protected areas through targets, thresholds, and social-ecological objectives

Frontiers in Marine Science
Marine Protected Areas (MPAs) are being deployed globally to protect the Earth’s biodiversity in rapidly changing oceans. Nesting climate change considerations within adaptive MPA management and monitoring is becoming a more common approach, and while ...
Kaia Bryce, Karen L. Hunter
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Validating the performance of direct fastening (PAF) into concrete with high‐speed measuring technology [PDF]

, 2023
Ronja Scholz, Pascal Franck, Alhussain Yousef, Panagiotis Spyridis, Frank Walther   +4 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Key Traffic Metrics as a Basis to Measure Library Performance

, 2020
О. M. Udartseva
openalex   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Core Measure Set for Patient Safety in Perioperative Care: A Clinical Practice-Oriented Consensus Study

International Journal of Public Health
ObjectivesTo develop a consensus-based EU-wide Core Measure Set (CMS), including patient-reported measures, for evaluating perioperative patient safety in routine adult care.MethodsA four-phase approach was applied: 1) identification of candidate ...
Ana Beatriz Nunes, José Pedro Teixeira, Andreia Leite, Andreia Leite, Willemijn Schäfer, Claudia Valli, Claudia Valli, Ismael Martínez-Nicolas, Ismael Martínez-Nicolas, Margarida Paixão, Ayshe Seyfulayeva, Daniel Treviño Abelenda, Anna Rodríguez, Anna Rodríguez, Pedro Casaca Carvalho, Anita Heideveld-Chevalking, Yvette Emond, Kaja Põlluste, Hiske Calsbeek, Daniel Arnal-Velasco, Daniel Arnal-Velasco, Adam Žaludek, Adam Žaludek, Pascal Garel, Cordula Wagner, Cordula Wagner, Oliver Groene, Oliver Groene, Carola Orrego, Carola Orrego, Carola Orrego, Paulo Sousa, SAFEST Scientific Advisory Group, SAFEST Scientific Executive Group, SAFEST Consortium   +34 more
doaj   +1 more source

B-97The Necessity of using Multiple Measures of Performance Validity in Neuropsychological Testing: A Case Study of Adolescent Concussion [PDF]

, 2015
Bradley T. Christian, Jacqueline M. Kiefel, M DiQuattro   +2 more
openalex   +1 more source