Results 61 to 70 of about 458,532 (218)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Navigating the Neoliberal maze: South African academics’ coping strategies in modern higher education

open access: yesSA Journal of Industrial Psychology
Orientation: The invasion of neoliberalism in higher education institutions as an ideology has significantly changed how these institutions are governed. The emergence is primarily aimed at emphasising market-driven and consumerist principles.
Nicolené van Vuuren
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Performance Metrics for Multilabel Emotion Classification: Comparing Micro, Macro, and Weighted F1-Scores

open access: yesApplied Sciences
This study compares various F1-score variants—micro, macro, and weighted—to assess their performance in evaluating text-based emotion classification. Lexicon distillation is employed using the multilabel emotion-annotated datasets XED and GoEmotions. The
Maria Cristina Hinojosa Lee   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The Role of Performance Metrics in Estimating Market Values of Footballers in Europe's Top Five Leagues

open access: yesPamukkale Spor Bilimleri Dergisi
The transfer economy in football is a multi-billion-dollar industry, where accurate valuation of players is crucial for clubs' financial sustainability and competitive success.
Murat Işık, Mehmet Ali Yalçınkaya
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research Progress and Trend Analysis of Hydrogen Liquefaction Technology

open access: yesZhileng xuebao
As a clean energy source, LH2 is poised to play a pivotal role in future energy supplies. Currently, international hydrogen liquefaction facilities suffer from high energy consumption, high liquefaction costs, and low exergy efficiencies.
Bi Yujing, Ju Yonglin
doaj  

Vehicle-to-Cyclist Collision Prediction Models by Applying Machine Learning Techniques to Virtual Reality Bicycle Simulator Data

open access: yesApplied Sciences
The study of vulnerable road users (VRUs) behavior is key to designing and optimizing driving assistance systems, such as the autonomous emergency braking (AEB) system. These kinds of devices could help lower the VRU accident rate, which is of particular
Ángel Losada   +5 more
doaj   +1 more source

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