Results 111 to 120 of about 10,322,171 (244)
Performance analysis of object-oriented designs for distributed systems [PDF]
, 1999 Performance is an important but often overlooked aspect of systems design. As a consequence, deployed software systems can fail to satisfy requirements and frequently disappoint customers and users. Successful systems are often achieved more by trial and
Utton, Peter +3 more
core
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Modelling the performance of speaker arrays in domestic listening environments. [PDF]
, 2017 The evaluation of multi-speaker arrays is often completed in ideal anechoic conditions to better enable the observation of speaker interaction at a known listening position.
Middlicott, Charlie +3 more
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Case studies in performance modelling and simulation of distributed information systems
, 1997 This paper has described the simulation model of the EDPEPPS environment. The modularity of the model allows a re-configuration of the parallel platform (e.g. the resource layer can be extended to model other networks such as Fast Ethernet of FDDI).
Poslad, S., Winter, S., Delaitre, T.
core
PERFORMANCE MODELLING OF DATABASE MANAGEMENT SYSTEMS.
, 1986 PERFORMANCE MODELLING OF DATABASE MANAGEMENT ...
LIEH-SAN. LIN (7987979)
core +3 more sources