Results 101 to 110 of about 1,004,191 (301)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Research, Development, Production and Performance of heavy duty CNG fleets in Iran [PDF]
In recent years, along with the trend toward clean air and less dependency to imported oil products, there has been increasing willing to use substitute fuels in transport industry.
Ale Ebrahim, Nader +2 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Pulse performance analysis for small hypergolic-propellant rocket engines [PDF]
Small rocket engine tests were conducted for the purpose of obtaining pulse performance data to aid in preliminary design and evaluation of attitude control systems.
Sforzini, R. H., Smith, G. W.
core +1 more source
Performance of family physicians (FPS) from viewpoint of managers and experts of northern provinces of Iran [PDF]
, 2015 BACKGROUND AND OBJECTIVE: Family physicianis (FPs) responsible for the health team have five duty to health management, external c00peration, Health Promotion, Prevention and Health Services and treatment care and referral. This study evaluated viewpoint
Amiri, H.A. +3 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Impact of Grating Duty-Cycle Randomness on DFB Laser Performance
PhotonicsThe duty-cycle randomness (DCR) of the Bragg grating of the distributed feedback (DFB) lasers introduced by the fabrication process is inevitable, even with state-of-the-art technologies such as electron beam lithography and dry or wet etching.This work ...
Manpo Yang, Xiangpeng Kong, Xun Li
doaj +1 more source
Supererogation and the Limits of Moral Obligations. Guest Editor’s Preface [PDF]
, 2017 Do moral obligations include all the good that can be possibly achieved? Does every instance of the good always entail obligatory performance?
Grigoletto, Simone
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Truss structure optimization of heavy-duty escalators via finite element analysis.
PLoS ONETo adapt to the characteristics of high load and long-term operation of heavy-duty escalators, traditional trusses often adopt redundant structural designs to meet higher safety and reliability requirements, resulting in increased self-weight and higher ...
Zimin Tang +5 more
doaj +1 more source