Results 71 to 80 of about 933 (213)

Perancangan Key Performance Indicator Divisi General Affairs Menggunakan Metode Performance Prism

Jurnal Penelitian Inovatif
Penelitian ini merancang Key Performance Indicators (KPI) untuk Divisi General Affairs (GA) pada perusahaan pengolahan hasil laut menggunakan metode Performance Prism dan Analytical Hierarchy Process (AHP). Pendekatan ini mencakup lima perspektif: kepuasan pemangku kepentingan, strategi, proses, kapabilitas, dan kontribusi pemangku kepentingan.
Dewi Aisarunnisa' Maunah, Dira Ernawati
openaire   +1 more source

Investigation of beam steering performances in rotation Risley-prism scanner

Optics Express, 2016
Rotation Risley-prism scanner appears to be the most promising solution to high-accuracy beam scanning and target tracking. In the paper, some important issues crucial to the function implementation are thoroughly investigated. First the forming law of scan blind zone relative to double-prism structural parameters is explored by a quantitative analysis
Anhu, Li, Wansong, Sun, Wanli, Yi, Qiyou, Zuo   +3 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The effect of Fresnel prisms on dynamic visual acuity

British and Irish Orthoptic Journal, 2010
Aim:  To investigate the effect of Fresnel prisms on dynamic visual acuity (DVA). Methods:  Sixteen participants with normal visual acuity aged between 18 and 22 years were tested monocularly with four strengths of base-out Fresnel prisms (0Δ, 5 Δ, 15 Δ,
Gail Maconachie, Helen Griffiths, David Buckley   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Performance of Pediatric Risk of Mortality IV in Brazilian PICUs: A Multicenter Prospective Study

Critical Care Explorations
IMPORTANCE:. This is the first Brazilian study evaluating the performance of Pediatric Risk of Mortality (PRISM) IV and the first to use the calibration belt technique. OBJECTIVES:.
Gustavo Rodrigues-Santos, MD, MSc, Arnaldo Prata-Barbosa, MD, PhD, Fernanda Lima-Setta, MD, PhD, Pedro Henrique Nunes Costa Silami, MD, MSc, Mariana Barros Genuíno de Oliveira, PT, MSc, Jaqueline Rodrigues Robaina, PSYCH, PhD, José Colleti Júnior, MD, PhD, Felipe Rezende Caino de Oliveira, Luís Fernando Andrade de Carvalho, MD, MSc, Mariana Digiovanni, MD, MSc, Ana Paula Novaes Bellinat, MD, Thiago Peres da Silva, MD, Taisa Roberta Ramos Nantes de Castilho, MD, Simone Camera Gregory, MD, Ana Carolina Cabral Pinheiro Scarlato, MD, Paula Marins Riveiro, MD, José Oliva Proença Filho, MD, Antonio José Ledo Alves da Cunha, MD, PhD, Maria Clara de Magalhães-Barbosa, MD, PhD, Claudia de Souza Lopes, MD, PhD, on behalf of the Brazilian Research Network in Pediatric Intensive Care (BRnet-PIC), Lenira Medeiros de Morais Daibes Rachid, Igor Bromonschenkel Brandão, Lucas Pulcheri, Thaís de Mello Cesar Bernardi, José Carlos Fernandes, Luiz Aurelio de Oliveira, Evane Cordeiro Franco, Cibele Cristina Manzoni Ribeiro Borsett, Roberto Sapolnik, Diogo Pedroso, Thallys Ramalho Suzart Alves, Alessandra Geisler Daud Lopes, Letícia Alves Andrade Albuquerque, Lara de Araújo Torreão, Márcio Miranda Brito, Carolina Friedrich Amoretti, Graziela de Araújo Costa, Jurema Amancio Mascarenhas, Wendell Paiva Vita   +39 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source