Results 71 to 80 of about 580,278 (245)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

HERBAL METHIONINE (METHIOREP®) IMPROVES GROWTH PERFORMANCE OF BROILER CHICKENS WITHOUT AFFECTING CARCASS CHARACTERISTICS AND BLOOD INDICES

Tropical and Subtropical Agroecosystems, 2017
Methiorep®, an herbal methionine premix, which is reported to contain herbal ingredients that mimic the activity of Methionine such as SAMe (S-Adenosyl Methionine) and phosphatidyl choline, have recently introduced to Nigeria animal feed industry.
O.J. Makinde, A.J. Ajibade, S.K. Omotugba, M.S. Tumburawa, E.A. Ibe, E. Opoola, O.S. Zaccheaus   +6 more
doaj  

Match running performance profiles of amputee football players at the national level. [PDF]

Sci Rep, 2023
Muracki J, Nowak M, Kawczyński A, Silva AF, Clemente FM.   +4 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Force-Velocity Profiles in Collegiate American Football Players

International Journal of Strength and Conditioning
The application of force-velocity (FV) profiling in American football has yet to be explored. Purpose: To measure and compare FV profiles in collegiate American football players grouped by position, and to determine if FV profiles could predict ...
Parker Hill, Ryan Ishihara, Trevor Short, Kody Cooke, Josh Elms, Trevor Sackmann, Paulette Yamada   +6 more
doaj   +1 more source

A high performance profile-biomarker diagnosis for mass spectral profiles [PDF]

BMC Systems Biology, 2011
Although mass spectrometry based proteomics demonstrates an exciting promise in complex diseases diagnosis, it remains an important research field rather than an applicable clinical routine for its diagnostic accuracy and data reproducibility. Relatively less investigation has been done yet in attaining high-performance proteomic pattern classification
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Dairy cow performance is associated with longitudinal microRNA profiles.

PLoS ONE
Modern high producing dairy cows are still affected by poor fertility and disease, despite improvements achieved through genetic selection programs.
Madison MacLeay, Francesc Xavier Donadeu, Georgios Banos   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source