Results 141 to 150 of about 11,105,784 (304)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Domestic Oil Price Variation and Economic Performance in Nigeria

open access: yesAdvanced Research in Economics and Business Strategy Journal
This analysis uses quarterly data from 2017Q1 to 2023Q4 to examine the consequences of the variations in oil prices on Nigeria's economic performance. In particular, domestic oil prices, the official exchange rate, the consumer price index, and economic
Sabiu Bariki Sani   +1 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

“We are Performance Philosophy Problems”: Towards an accessible Performance Philosophy? [PDF]

open access: yes
This article originates from a KeyGroup presentation at the June 2022 Performance Philosophy Problems conference in Helsinki in which the performers of Different Light Theatre Company, a learning-disabled theatre company based in Christchurch, New ...
Janet Gibson   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Texas School Performance Reviews

open access: yes, 2002
A performance review of Austin Community College on its use of funding in different areas of the ...
Texas School Performance Review (Agency)
core  

Lexical indicators of L2 writing performance

open access: yesLiteracy Trek, 2019
Performance in L2 writing is a complex phenomenon which encompasses complexity, accuracy and fluency. However, relevant literature indicates that lexical performance also plays a role in L2 writing performance as a whole.
Kutay Uzun
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluation of Vibration Performance Variation of Rolling Bearing based on Fuzzy-set Theory

open access: yesJixie chuandong, 2018
In view of the deficiencies of peak factor,pulse factor and kurtosis factor in the monitoring of rolling bearing running condition,a new method to evaluate the variation of vibration performance of rolling bearing is proposed based on the fuzzy-set ...
Xia Xintao, Chen Xiangfeng, Cheng Li
doaj  

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