Results 231 to 240 of about 11,105,784 (304)

Integrating Traditional Machine Learning and Convolutional Neural Networks Into the Geometric Morphometric Pipeline for Taxonomic Classification (GM-ML-CNN). [PDF]

Integr Org Biol
Deku G, Combey R.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Development of the UK Severe Asthma Registry as a performance-monitoring quality improvement platform. [PDF]

BMJ Open Qual
Pfeffer PE, Brown T, Kramer Fiala Machado A, Patel M, Gonem S, Patel PH, Idris E, Shrikrishna D, Prior K, Mansur AH, Burhan H, Chaudhuri R, Gore R, Nanzer AM, Naveed S, Clifton IJ, Pantin T, Faruqi S, Shrimanker R, Doherty M, Jackson DJ, Doe S, Message S, Redmond C, Busby J, Heaney LG, Rupani H, UK Severe Asthma Registry.   +27 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The coefficient of variation of CT values for predicting lymph node metastasis in extrahepatic cholangiocarcinoma. [PDF]

PLoS One
Chiba N, Abe Y, Kojima H, Suda R, Nakagawa M, Ochiai S, Gunji T, Sano T, Tabuchi S, Ishizaki T, Kawachi S.   +10 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Financial dynamics and post-pandemic recovery of a public multidisciplinary hospital in Kazakhstan: a five-year financial case study. [PDF]

Front Public Health
Alimbetova M, Kurakbayev K, Ismailov Z, Najhawan R, Akimbaeva Z, Baimuratova M, Kassenova M.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Multi-model assessment of yield stability in lentil across multi-environments. [PDF]

PLoS One
Asghar MJ, Ghaffar M, Shahid M, Akhtar KP, Hameed A, Tabasum A, Rabbani G, Javed U, Shahbaz MU, Kamran M, Ehtisham-Ul-Haq M.   +10 more
europepmc   +1 more source