Results 251 to 260 of about 13,570,675 (340)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assigned vs. observed relative age: the association of early entry to school on cognitive abilities and its implications for educational practice. [PDF]

Front Psychol
Roden I, Wattie N, Bongard S, Schorer J.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Learning and Transfer of Graphomotor Skills in Three 7- to 10-Year-Old Children with Developmental Coordination Disorder: Case Reports. [PDF]

Children (Basel)
Josseron L, Clerc J, Jolly C.
europepmc   +1 more source

The plasma nanoDSF denaturation profiles predict the presence of breast cancer. [PDF]

J Transl Med
Guerin M, Eyraud R, Tsvetkov P, Finetti P, Giraudo A, Tarpin C, Hassin A, Bechlian D, Mamessier E, Pakradouni J, Boher JM, Goncalves A, Devred F, Bertucci F.   +13 more
europepmc   +1 more source

AIR-LEISH: A Dataset of Giemsa-Stained Microscopy Images for AI-based Leishmania amastigotes Detection. [PDF]

Sci Data
Oualha R, Fekih-Romdhane N, Driss D, Abdelkrim YZ, Guizani I, Harigua-Souiai E.   +5 more
europepmc   +1 more source

Machine Learning-Enhanced Evaluation of Handheld Laser-Induced Breakdown Spectroscopy (LIBS) Analytical Performance for Multi-Element Analysis of Rock Samples. [PDF]

Sensors (Basel)
Senesi GS, De Pascale O, Allegretta I, Terzano R, Marangoni B.   +4 more
europepmc   +1 more source

Performative and Performativity

, 2015
openaire   +1 more source