Results 51 to 60 of about 135,573 (306)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Nematicidal Action of Microencapsulated Essential Oil of Flesh Fingered Citron

Journal of Chemistry, 2020
Flesh fingered citron (FFC) essential oil (EO) is susceptible to volatilisation at room temperature. Therefore, its use as a nematicide requires a controlled release.
Xixi Piao, Lirong Zhang, Songxing Zhang, Fengping Yi   +3 more
doaj   +1 more source

Jenis Tanda Dalam Iklan Parfum (Sebuah Analisis Semiotik) [PDF]

, 2016
This research aims to identify and classify the kinds of sign and to analyze the connotation meaning that can be found on perfume advertisements. This research uses Pierce\u27s theory based on its\u27 object which are icon, index and symbol and in ...
LANGI, C. (CHRISTY)
core  

Timed k-Tail: Automatic Inference of Timed Automata

, 2017
Accurate and up-to-date models describing the be- havior of software systems are seldom available in practice. To address this issue, software engineers may use specification mining techniques, which can automatically derive models that capture the ...
Mariani, Leonardo, Micucci, Daniela, Pastore, Fabrizio   +2 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Psychopathic Personality Reflected In Tom Tykwer’s Perfume: The Story Of A Murderer (2006) [PDF]

, 2014
(Aprilia Riyana Putri, S 200 110 012, 2014. Psychopathic Personality Reflected in Tom Tykwer’s Perfume : the Story of a Murderer (2006)). Thesis. Magister of Language and Study. Faculty of Language Department.
, Dr. M. Thoyibi, M.S, , Dr. Phil. Dewi Candraningrum, M.Ed., Putri, Aprilia Riyana   +2 more
core  

Rapid evolution of chemosensory receptor genes in a pair of sibling species of orchid bees (Apidae: Euglossini). [PDF]

, 2015
BackgroundInsects rely more on chemical signals (semiochemicals) than on any other sensory modality to find, identify, and choose mates. In most insects, pheromone production is typically regulated through biosynthetic pathways, whereas pheromone sensory
Brand, Philipp, Eltz, Thomas, Leese, Florian, Quezada-Euan, J Javier G, Ramírez, Santiago R, Tollrian, Ralph   +5 more
core   +3 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Study on the Effect of Dalbergia pinnata (Lour.) Prain Essential Oil on Electroencephalography upon Stimulation with Different Auditory Effects

Molecules
Dalbergia pinnata (Lour.) Prain (D. pinnata) is a valuable medicinal plant, and its volatile parts have a pleasant aroma. In recent years, there have been a large number of studies investigating the effect of aroma on human performance.
Xin He, Sheng Qin, Genfa Yu, Songxing Zhang, Fengping Yi   +4 more
doaj   +1 more source