Results 181 to 190 of about 1,089 (257)

Tomografía de impedancia eléctrica en la lesión pulmonar aguda

La tomografía de impedancia eléctrica se ha descrito como un nuevo método de monitorización en el paciente crítico en ventilación mecánica. Recientemente ha cobrado especial interés, debido a su aplicabilidad para la monitorización de la ventilación y la
Casan, Pere, Jordi, Riera, Riu Costa, Pere Joan, Masclans, Josep Ramon   +3 more
core  

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

Regenerative therapies for complex diabetic foot wounds: a therapeutic challenge. [PDF]

J Vasc Bras
Grillo VTRDS, Romio EA, Sousa CD, Ranite GG, da Silva WR, Melluci PL, de Oliveira FJ, Bertanha M.   +7 more
europepmc   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

[Infectious tenosynovitis as an unusual focus of septic shock: A case report]. [PDF]

Aten Primaria
Mora-Aznar M, Ferrer-Sorolla R, Del Villar-Sordo V.   +2 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Impact of invasive mechanical ventilation support on renal function in critically ill patients. [PDF]

Rev Esc Enferm USP
Rocha JMS, Duarte TTDP, Ipolito MZ, Santos WS, Magro PPM, Magro MCDS.   +5 more
europepmc   +1 more source

Perfusión continua de urokinasa en hemodiálisis

, 2005
García-Miguel Vela, Marta, Vela Muñoz, María José, Muñoz Correas, Ana Belén   +2 more
core  

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Integrating computational fluid dynamics into organ-on-chip systems: a glioblastoma-centred design and validation framework. [PDF]

Front Bioeng Biotechnol
Taleban H, Li X, Ali Z, Kalesh K, Prakash J, Bagci-Onder T, Breznik B.   +6 more
europepmc   +1 more source