Results 291 to 300 of about 907,151 (342)

The Role of CT Perfusion in the Evaluation and Management of Acute Ischemic Stroke-A Systematic Review. [PDF]

Life (Basel)
Bobe RC, Coroiu RE, Cirstian AE, Cristescu CI, Pepelea DA, Manea RM.   +5 more
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Takotsubo syndrome with apical thrombosis associated with hyperthyroidism crisis: a case report from high-altitude Tibet. [PDF]

Front Cardiovasc Med
Zhang J, Yin L, Zhang Q.
europepmc   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

The Effectiveness and Safety of Cardiac Shock Wave Therapy in the Treatment of Ischemic Heart Disease with Refractory Angina Pectoris. [PDF]

Vasc Health Risk Manag
Thanh LD, Bien VD, Son PN, Pho DC, Huy PX, Tuan NV, Giang PT.   +6 more
europepmc   +1 more source

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration. [PDF]

Mil Med Res
Haastert-Talini K, Katsirntaki K, Kankowski S, Kaltenborn A, von Lübken F, Falk C, Werlein C, Jonigk D, Ruhparwar A, Wiegmann B.   +9 more
europepmc   +1 more source

Quantitative Evaluation of Lung Perfusion by Dynamic Chest Radiography in Chronic Thromboembolic Pulmonary Hypertension: Comparison With Lung Perfusion Scintigraphy. [PDF]

Pulm Circ
Ikeda M, Yamasaki Y, Sagiyama K, Hosokawa K, Toyomura D, Hida T, Hino T, Tabata K, Isoda T, Matsutani N, Yabuuchi H, Abe K, Akashi K, Ishigami K.   +13 more
europepmc   +1 more source

Brain Perfusion Scintigraphy in the Diagnostic Toolbox for the Confirmation of Brain Death: Practical Aspects and Examination Protocol. [PDF]

Diagnostics (Basel)
Günther A, Gunkel A, Geis C, Brämer D, Brauer M, Doerfel C, Fritzenwanger M, Freesmeyer M, Winkens T, Drescher R, Werner A.   +10 more
europepmc   +1 more source

Multimodal assessment of peripheral perfusion in critically ill patients: a pilot study. [PDF]

Ann Intensive Care
Demailly Z, Modica E, Vitali E, Sousa F, Dragoni C, Zernini IS, Annicchiarico C, Dehout C, Tamion F, Besnier E, Njimi H, Dos Santos EC, Taccone FS.   +12 more
europepmc   +1 more source