Results 171 to 180 of about 263,898 (315)

Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications

Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making.
Thomas, D.L., Golay, Xavier, Wang, D.J.J., Macintosh, B.J., Warnert, Esther A. H., Okell, T.W., Hernandez‐Garcia, Luis, Wang, Danny J., Okell, Thomas W, Osch, Matthias J.P. van, Ho, Mai-Lan, Achten, E., Qin, Qin, Zhao, Moss Y., Mutsaerts, Henk Jmm, Chappell, Michael A, Detre, John A, Dai, W.Y., Smits, Marion L.J., Warnert, E.A.H., Wang, Danny JJ, Parkes, Laura M, Zhao, M.S., Smits, Marion, Smits, M., Woods, Joseph G., Fan, A.P., Detre, John A., Osch, M.J.P. van, Fernández-Seara, M.A., Zelaya, Fernando; id_orcid, Warnert, Esther AH, Chappell, M.A., Okell, Thomas W., Fernández-Seara, María A., Madhuranthakam, Ananth J, Parkes, Laura M., Pinto, Joana, Wang, Danny J.J., Suzuki, Y., Fernández‐Seara, María A., Detre, J.A., Suzuki, Yuriko, Ho, Mai Lan, Ho, Mailan, Bolar, Divya S, Günther, M., Juttukonda, Meher R, Pinter, N., MacIntosh, Bradley J., Mutsaerts, H.J., Hernandez-Garcia, Luis, Fan, Audrey P, Günther, Matthias, Asllani, I., Smits, Marion; id_orcid, Mutsaerts, Henk‐Jan, Pinter, Nandor K., Juttukonda, Meher R., Pinto, J., Guo, J., Zelaya, Fernando O., Qin, Q., Thomas, David L, MacIntosh, Bradley J, Woods, Joseph G, ISMRM Perfusion Study Grp, Juttukonda, M.R., Zaharchuk, Greg, Van Osch, Matthias J.P., Parkes, Laura M.; id_orcid, Hernandez-Garcia, L., Warnert, Esther A.H., Mutsaerts, Henk-Jan, Parkes, L.M., Zaharchuk, G., Woods, J.G., Bolar, Divya S., Fan, Audrey P., Zelaya, Fernando, Van Osch, Matthias J. P., Wang, Danny J. J., Thomas, David L., Asllani, Iris, Madhuranthakam, Ananth J., Dai, Weiying, Zhao, Moss, Bolar, D.S., Zelaya, F., Ho, Mai‐Lan, Ho, M.L., Lu, H.Z., Golay, X., Madhuranthakam, A.J., the ISMRM Perfusion Study Group, Mutsaerts, Henk Jan, Lu, Hanzhang, Van Osch, Matthias JP, Chappell, Michael A., Achten, Eric, Fernández‐Seara, María A, Pinter, Nandor, Guo, Jia   +102 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Quantitative myocardial perfusion imaging across PET, SPECT, CMR, and CT. [PDF]

Front Radiol
Kato Y, Chehab O, Ambale-Venkatesh B, Lima JAC.   +3 more
europepmc   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Deep Learning-Based Automatic Segmentation of Ischemic Stroke Lesions in CT Perfusion Imaging. [PDF]

Biomimetics (Basel)
Zare Lahijan L, Meshgini S, Afrouzian R.
europepmc   +1 more source

LASER DOPPLER PERFUSION IMAGING WITH A PLURALITY OF BEAMS

, 2003
Laser Doppler Perfusion Imaging system including a laser light source 2, an image detector 4, and signal detector 6 the laser light source 2, in use, being arranged for illuminating a selected area of interest 12 on a sample 10 for determining perfusion ...
de Mul, F.F.M., Serov, Alexander, Steenbergen,, Wiendelt   +2 more
core  

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Risk stratification with pre-operative myocardial perfusion imaging. [PDF]

Eur J Nucl Med Mol Imaging
Kim D, Builoff V, Sharir T, Hauser MT, Dorbala S, Di Carli MF, Fish MB, Ruddy TD, Bateman TM, Einstein AJ, Kaufmann PA, Miller EJ, Sinusas AJ, Acampa W, Halcox J, Dey D, Berman DS, Miller RJH, Slomka PJ.   +18 more
europepmc   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source