Results 211 to 220 of about 123,390 (306)

Dual-energy CT based low flow rate, low dose CTPA and lung perfusion in the pulmonary diagnosis of post-COVID-19 syndrome. [PDF]

Front Med (Lausanne)
Jing Z, Cui L.
europepmc   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Sevoflurane-induced hemispheric cerebral blood flow reduction in mice with revived global perfusion after carotid artery occlusion. [PDF]

Eur J Med Res
Hao R, Li J, Cang J, Fang F.
europepmc   +1 more source

Imaging and modeling the blood circulation through the liver and kidney [PDF]

, 2016
Debbaut, Charlotte, Monbaliu, Diethard, Peeters, Geert, Segers, Patrick   +3 more
core  

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Alzheimer's disease diagnosis support for brain perfusion SPECT scans in a real-world clinical cohort. [PDF]

J Alzheimers Dis
Michopoulou S, Prosser A, O'Brien N, Dickson J, Guy M, Teeling JL, Kipps CM.   +6 more
europepmc   +1 more source

Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes

Advanced Science, EarlyView.
The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui, Neela K. Codadu, Daman Rathore, Guanghui Li, Marcello Meneghetti, Anders L. Bøcker, Rune W. Berg, Rob C. Wykes, Christos Markos   +8 more
wiley   +1 more source

Exploratory Research of Intraductal Chemotherapy to Control the Focal Breast Lesion of Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Lin X, Li X, Wei Q, Yuan H, Zhong M, Qiao J, Gong J, Li Y.   +7 more
europepmc   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Dual-energy CT biomarkers for predicting the efficacy of TACE combined with lenvatinib and immune checkpoint inhibitors in unresectable HCC. [PDF]

Eur Radiol Exp
Zhang J, Zhang K, Du T, Yan C, Wang Y, Gao M, Han J, Zhang M, Chen Y, Zhao L.   +9 more
europepmc   +1 more source