Results 61 to 70 of about 123,390 (306)

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

The Legacy of the TTASAAN Report – Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II

Frontiers in Neurology, 2022
Brain perfusion single photon emission computed tomography (SPECT) scans were initially developed in 1970s. A key radiopharmaceutical, hexamethylpropyleneamine oxime (HMPAO), was not stabilized until 1993 and most early SPECT scans were performed on ...
Dan G. Pavel, Dan G. Pavel, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Simon DeBruin, Simon DeBruin, Philip F. Cohen, Philip F. Cohen, Philip F. Cohen   +11 more
doaj   +1 more source

A Comparative Study for 2D and 3D Computer-aided Diagnosis Methods for Solitary Pulmonary Nodules [PDF]

, 2008
Many computer-aided diagnosis (CAD) methods, including 2D and 3D approaches, have been proposed for solitary pulmonary nodules (SPNs). However, the detection and diagnosis of SPNs remain challenging in many clinical circumstances.
Lin, Chen-Liang, Nagurka, Mark L., Wang, Jen-Feng, Wu, Ming-Ting, Yeh, Chinson, Yen, Chen-Wen   +5 more
core   +1 more source

Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry. [PDF]

, 2019
To evaluate the association between a vessel size index (VSIMRI) derived from dynamic susceptibility contrast (DSC) perfusion imaging using a custom spin-and-gradient echo echoplanar imaging (SAGE-EPI) sequence and quantitative estimates of vessel ...
Chakhoyan, Ararat, Cloughesy, Timothy F, Ellingson, Benjamin M, Everson, Richard G, Lai, Albert, Leu, Kevin, Liau, Linda M, Nathanson, David A, Nghiemphu, Phioanh L, Pope, Whitney B, Prins, Robert M, Salamon, Noriko, Yao, Jingwen, Yong, William   +13 more
core   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

A simplified method to correct saturation of arterial input function for cardiac magnetic resonance first-pass perfusion imaging: validation with simultaneously acquired PET

Journal of Cardiovascular Magnetic Resonance, 2023
Background First-pass perfusion imaging in magnetic resonance imaging (MRI) is an established method to measure myocardial blood flow (MBF). An obstacle for accurate quantification of MBF is the saturation of blood pool signal intensity used for arterial
Ran Li, Masoud Edalati, David Muccigrosso, Jeffrey M. C. Lau, Richard Laforest, Pamela K. Woodard, Jie Zheng   +6 more
doaj   +1 more source

Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates. [PDF]

, 2020
Cell-derived extracellular matrix (ECM) provides a niche to promote osteogenic differentiation, cell adhesion, survival, and trophic factor secretion.
Genetos, DC, Gonzalez-Fernandez, T, Harvestine, JN, Hum, NR, Leach, JK, Loots, GG, Sebastian, A   +6 more
core  

Using a Conformal Water Bolus to Adjust Heating Patterns of Microwave Waveguide Applicators [PDF]

, 2017
Background: Hyperthermia, i.e., raising tissue temperature to 40-45°C for 60 min, has been demonstrated to increase the effectiveness of radiation and chemotherapy for cancer.
Dewhirst, Drizdal, Drizdal, Hasgall, Neufield, Rodrigues, Stauffer, Stauffer, Trefna, van Rhoon   +9 more
core   +2 more sources

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Advanced Functional Materials, EarlyView.
A 3D bioprintable microporous bioink is developed using an aqueous two‐phase system (ATPS) composed of extracellular matrix (ECM) mimetic biopolymers. The ATPS bioink enables the fabrication of interconnected porous architectures with up to 70% porosity, supporting long‐term cell viability and 3D cell alignment, enabling a simultaneous generation of ...
Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source