Results 241 to 250 of about 62,684 (271)

Comparison of MRI and Endoanal Ultrasound in Assessing Intersphincteric, Transsphincteric, and Suprasphincteric Perianal Fistula

Journal of Ultrasound in Medicine, 2023
Perianal fistula is a common disorder characterized by an anomalous perianal track connecting two epithelialized surfaces, most commonly the anal canal and the perianal skin.
Neda Akhoundi
exaly   +2 more sources

Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex perianal fistula in non‐Crohn's cases: Clinical trial phase I

Journal of Gastroenterology and Hepatology, 2023
A perianal fistula is an abnormal tract that connects anal canal to skin. Current medical and surgical interventions have a high failure rate particularly in complex and refractory cases.
Haleh Pak, Alireza Hadizadeh, A. Heirani-Tabasi, M. Soleimani, Reza Akbari Asbagh, M. Fazeli, A. Kazemeini, A. Keshvari, M. Keramati, F. Salahshour, Hengameh Nazari, Seyed Mohsen Ahmad Tafti, B. Behboudi   +12 more
semanticscholar   +1 more source

A Phase IB/IIA Study of Ex Vivo Expanded Allogeneic Bone Marrow–Derived Mesenchymal Stem Cells for the Treatment of Perianal Fistulizing Crohn’s Disease

Diseases of the Colon & Rectum, 2023
BACKGROUND: Mesenchymal stem cells have been used for the treatment of perianal Crohn’s fistulizing disease by direct injection. However, no studies to date have included patients with proctitis, anal canal involvement, and multiple branching tracts ...
A. Lightner, J. Reese, Justin Ream, D. Nachand, Xue Jia, N. Dadgar, S. Steele, T. Hull   +7 more
semanticscholar   +1 more source

Pathogenesis of Perianal Fistulizing Crohn's Disease: Current knowledge, gaps in understanding and future research directions.

Journal of Crohn's & Colitis, 2023
Fistulizing perianal involvement is a common presentation of Crohn's disease. Perianal Crohn's disease dramatically impairs patients' social and sexual life and its management remains a critical challenge in field of inflammatory bowel disease.
Siyan Cao, M. Colonna, Parakkal Deepak
semanticscholar   +1 more source

Case 24-2022: A 31-Year-Old Man with Perianal and Penile Ulcers, Rectal Pain, and Rash.

New England Journal of Medicine, 2022
Dr. Vivian De Oliveira Rodrigues Gama (Medicine): A 31-year-old man was admitted to this hospital because of perianal and penile ulcers, rectal pain, and vesiculopustular rash.
N. Basgoz, C. M. Brown, S. Smole, L. Madoff, P. Biddinger, Joshua J. Baugh, Erica S. Shenoy   +6 more
semanticscholar   +1 more source

Perianal fistulas: A review with emphasis on preoperative imaging.

Advances in Medical Sciences, 2022
PURPOSE We aim to present a comprehensive literature review which focuses on the preoperative imaging of perianal fistulas. MATERIAL/METHODS Pelvic magnetic resonance imaging (MRI) and endoanal ultrasound (EAUS) are the two first-line imaging ...
N. Varsamis, C. Kosmidis, G. Chatzimavroudis, K. Sapalidis, C. Efthymiadis, Fani Apostolidou Kiouti, A. Ioannidis, C. Arnaoutoglou, P. Zarogoulidis, I. Kesisoglou   +9 more
semanticscholar   +1 more source

A Microbial Signature for Pediatric Perianal Crohn's Disease.

Journal of Crohn's & Colitis, 2022
BACKGROUND & AIMS Perianal fistulizing disease can affect up to 25% of patients with Crohn's disease (CD) and lead to significant morbidity. While the role of the gut microbiota in inflammatory bowel disease (IBD) has been increasingly recognized, its ...
J. Breton, Ceylan Tanes, Vincent Tu, L. Albenberg, S. Rowley, N. Devas, R. Hwang, K. Kachelries, Gary D. Wu, R. Baldassano, K. Bittinger, P. Mattei   +11 more
semanticscholar   +1 more source

Ustekinumab for Perianal Crohn's Disease: The BioLAP Multicenter Study From the GETAID.

American Journal of Gastroenterology, 2020
INTRODUCTION New therapeutic options for patients with Crohn's disease (CD) with perianal lesions failing anti-tumor necrosis factor (TNF) agents are needed.
Constance Chapuis-Biron, J. Kirchgesner, B. Pariente, Y. Bouhnik, A. Amiot, S. Viennot, M. Serrero, M. Fumery, M. Allez, L. Siproudhis, A. Buisson, Guillaume P. Pineton de Chambrun, V. Abitbol, S. Nancey, L. Caillo, L. Plastaras, G. Savoye, E. Chanteloup, M. Simon, N. Dib, Sylvie Rajca, M. Amil, A. Parmentier, L. Peyrin-Biroulet, L. Vuitton   +24 more
semanticscholar   +1 more source

Vedolizumab for perianal Crohn’s disease: a multicentre cohort study in 151 patients

Alimentary Pharmacology and Therapeutics, 2020
The management of Crohn's disease patients with perianal lesions and anti‐TNF failure is challenging.
Constance Chapuis-Biron, A. Bourrier, M. Nachury, S. Nancey, Y. Bouhnik, M. Serrero, L. Armengol-Debeir, A. Buisson, My-Linh Tran-Minh, C. Zallot, M. Fumery, G. Bouguen, V. Abitbol, S. Viennot, E. Chanteloup, Sylvie Rajca, N. Dib, A. Parmentier, L. Peyrin-Biroulet, L. Vuitton   +19 more
semanticscholar   +1 more source

Perianal Crohn’s Disease Is Associated With Poor Disease Outcome: A Nationwide Study From the epiIIRN Cohort

Clinical Gastroenterology and Hepatology, 2022
Ohad Atia, Oren Ledder, Dan Turner
exaly