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Perilymph fistula pathophysiology

Otolaryngology–Head and Neck Surgery, 1995
A great deal of the controversy associated with perilymph fistula is due to the lack of a sensitive, specific way of detecting and thus diagnosing one. The existing subjective, clinical observations need to be replaced with an objective, scientific methodology having higher specificity and sensitivity for the detection of perilymph fistula.
C, Wall, S D, Rauch
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The Origin of Perilymph Albumin

Acta Oto-Laryngologica, 1968
Results are presented of analyses of serum, CSF, perilymph and endolymph electrophoretic mobilities in 24 cadaver ears. On an average, perilymph and CSF albumin had identical mobility whereas the mobility index of serum albumin was clearly slower than the other two.
T, Palva, V, Raunio
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The blood-perilymph barrier

Archives of Oto-Rhino-Laryngology, 1980
Freeze fracture replicas of the guinea pig inner ear were studied under the electron microscope to define the blood-perilymph barrier morphologically. This barrier is represented basically by the continuous endothelium of the inner ear capillaries. The endothelial cells contain only a few micropinocytotic vesicles in contrast to those of the stria ...
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CSF-Specific Proteins in Perilymph

Acta Oto-Laryngologica, 1971
Using antisera against CSF and absorbed with normal human plasma, two precipitate arcs formed between anti-CSF-well, and CSF-well and perilymph in two cases of acoustic neuroma. This proves without doubt that the perilymph proteins have, at least in part, their origin in the CSF space.
T, Palva, V, Raunio
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A Contribution to the Physiology of the Perilymph Part I: The Origins of Perilymph

Annals of Otology, Rhinology & Laryngology, 1974
Perilymph may as a first approximation be considered an ultrafiltrate of blood. Under quasi-stationary conditions there is a balance of concentrations of nonproteinbound low molecular weight substances in the blood and perilymph, the blood concentration being the governing factor.
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Pharmacology of Perilymph Production

ORL, 2010
Perilymph is considered the sole source of nutritional supply to the cochlear hair cells as well as the sole carrier for the elimination of metabolites. An increase of the perilymph turnover rate implies an improvement of the hair cell metabolism. Any drug that enhances perilymph production might be a useful agent for the treatment of acute inner ear ...
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Perilymph fistula—a diagnostic dilemma

The Journal of Laryngology & Otology, 1991
AbstractA retrospective series is presented of 51 cases operated on for suspected perilymph fistula. In 26 ears a fistula was identified at surgery. A positive fistula test was found to strongly indicate a perilymph fistula but was more often negative than positive in surgically demonstrated fistula ears.
E, Vartiainen   +3 more
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Perilymph fistula: the patients' experience

The Journal of Laryngology & Otology, 2016
AbstractObjective:This study aimed to assess the experiences and outcomes of patients who underwent surgical repair of a perilymph fistula in Norfolk, UK.Methods:The study involved a retrospective questionnaire-based patient survey and case note review of patients who had undergone tympanotomy and perilymph fistula repair between 1998 and 2012 in two ...
J A, Meldrum, P R, Prinsley
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The Total Protein of Human Perilymph

Acta Oto-Laryngologica, 1969
Total protein values were determined from the perilymph of 47 cadaver ears. After subtraction of hemoglobin the average total protein for two series of 27 and 10 ears was 553 and 559 mg%, respectively. When the perilymph specimens were taken directly without freezing the average total protein figures were reduced to 280 (cochlea) or 312 mg% (vesti ...
T, Palva, V, Raunio
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Perilymph fistula: The iowa experience

The Laryngoscope, 1986
AbstractNinety‐one patients with demonstrable perilymph fistulas presented with an amazing array of signs and symptoms ranging from unilateral tinnitus and aural fullness to sudden‐and‐profound hearing loss, roaring tinnitus, and whirling vertigo. Between 1977 and 1984, 214 exploratory tympanotomies for suspected perilymph fistula (PLF) were performed ...
S, Seltzer, B F, McCabe
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