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Hyperammonemia and Perinatal Asphyxia

Pediatrics, 1981
In a recent article Goldberg et al1 presented data on 12 asphyxiated newborn infants with high ammonia levels concomitant with abnormal liver function tests. They pointed out that the liver dysfunction, probably secondary to the ischemic-hypoxic injury, might have contributed to ammonia elevation by decreasing urea biosynthesis.
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Consequences of Perinatal Asphyxia

AACN Advanced Critical Care, 1994
Perinatal asphyxia occurs in 3–9 of every 1,000 births. The risk for perinatal asphyxia is present in every pregnancy. When asphyxia is diagnosed in a newborn, the effects on the infant are potentially life-threatening. Management of the asphyxia focuses on initial stabilization and support based on identified organ system dysfunction as well as ...
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Perinatal asphyxia and cardiac abnormalities

International Journal of Cardiology, 2011
The most common etiologies of myocardial infarction in the perinatal period are congenital heart disease, coronary artery lesions, thromboembolism and perinatal asphyxia. Cardiac abnormalities in perinatal asphyxia include tricuspid regurgitation and mitral regurgitation associated with transient myocardial ischemia of the newborn. Patent foramen ovale
DATTILO, GIUSEPPE   +6 more
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Neurological Aspects of Perinatal Asphyxia

Developmental Medicine & Child Neurology, 1974
SUMMARYNeurological findings in the newborn period are presented from a series of 94 infants who were selected from 760 asphyxiated newborn infants on the basis of seven criteria—feeding difficulties, apnoeic and cyanotic attacks, apathy, convulsions, hypothermia, persistent vomiting and a high‐pitched cerebral cry.
J K, Brown   +3 more
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The Definition of Acute Perinatal Asphyxia

Clinics in Perinatology, 1993
Perinatal asphyxia remains a concern for physicians, patients, and attorneys. The history of concern for this condition is reviewed, and efforts in neonatal-perinatal medicine to identify at risk patients and prevent serious sequelae are discussed.
B S, Carter   +2 more
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Perinatal Asphyxia: Clinical Aspects

Clinics in Perinatology, 1989
This article reviews the significance of hypoxic-ischemic encephalopathy and the associated patterns of cerebral injury in the context of the most probable timing of the insult and prognosis. The evolution of the clinical features of significant hypoxic-ischemic encephalopathy, and the diagnostic value of imaging and electrophysiologic and metabolic ...
A, Hill, J J, Volpe
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Hyperammonemia Associated with Perinatal Asphyxia

Pediatrics, 1979
Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 µg/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurologic dysfunction in five of seven infants.
R N, Goldberg   +4 more
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Hepatic involvement in perinatal asphyxia

The Journal of Maternal-Fetal & Neonatal Medicine, 2007
The pathogenetic mechanisms of hepatic injury in perinatal asphyxia (PNA) are similar to those in ischemic hepatitis, yet liver involvement is currently not considered a component of multi-organ failure in PNA.A retrospective study was done on 56 newborns with PNA. Hepatocyte injury was diagnosed based on elevated serum alanine transaminase level (>100
Aylin, Tarcan   +3 more
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Oxidative Stress in Perinatal Asphyxia

Pediatric Neurology, 2008
Oxygen free radicals may cause tissue injury in perinatal asphyxia. We measured plasma and cerebrospinal fluid levels of malondialdehyde and plasma levels of glutathione peroxidase, catalase, and superoxide dismutase in 50 term newborns with perinatal asphyxia and eight newborns without asphyxia.
Ashok, Kumar   +3 more
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Systemic Effects of Perinatal Asphyxia

The Indian Journal of Pediatrics, 2014
Perinatal asphyxia is one of the three most important causes of neonatal mortality and morbidity [1]. It is a major contributor to long term neurodevelopmental sequele in the developing world. During fetal hypoxia-ischemia, ‘diving reflex’ shunts blood from ‘non-vital areas’ such as skin and splanchnic circulation to the ‘vital organs’ like heart ...
Anuj, Bhatti, Praveen, Kumar
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