Results 191 to 200 of about 112,303 (259)

HucMSC‐Derived Exosomes Preserve Mafb‐Dependent Tubular Epithelial Identity and Suppress Dedifferentiation in Obstructive Nephropathy

open access: yesPediatric Discovery, EarlyView.
Unilateral ureteral obstruction (UUO) and genetic deletion of Mafb lead to tubular epithelial dedifferentiation, characterized by decreased E‐cadherin and increased α‐SMA and vimentin expression. Intravenous administration of human umbilical cord mesenchymal stem cell‐derived exosomes (HucMSC‐Exos) partially restores Mafb expression in UUO kidneys ...
Zhuocheng Shi   +5 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux   +6 more
wiley   +1 more source

How Does SNAP Access Prior to Pregnancy Affect Maternal and Infant Health Outcomes?

open access: yesThe Milbank Quarterly, EarlyView.
Policy Points Reimposing work requirements for the Supplemental Nutrition Assistance Program—by removing temporary, location‐based waivers—causes a decline in food assistance participation among childless women. This loss of nutritional support prior to pregnancy is linked to tangible, negative health outcomes for their infants.
SARAH HAMERSMA, MITCHELL MCFARLANE
wiley   +1 more source

Towards the Development of a Conceptual Framework of the Determinants of Pre‐Eclampsia: A Hierarchical Systematic Review of Social Determinants

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Existing reviews of pre‐eclampsia determinants have focused on clinical and genetic risk factors. Objective To evaluate social determinants for pre‐eclampsia prevention. Search Strategy Systematic searches were conducted from relevant electronic databases from inception of each database to 30th December 2024.
Mai‐Lei Woo Kinshella   +16 more
wiley   +1 more source

Towards the Development of a Conceptual Framework of the Determinants of Pre‐eclampsia: A Hierarchical Systematic Review of Biomarkers

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Pre‐eclampsia is a leading cause of maternal and perinatal morbidity and mortality. There are several determinants of individual pregnant women's risk of developing pre‐eclampsia, including biomarkers and ultrasound markers. Objective A conceptual framework to collate and summarise the extensive body of literature on biomarkers ...
Terteel Elawad   +89 more
wiley   +1 more source

Differences in Risk Factors for Severe Preeclampsia and HELLP Syndrome in Singleton Versus Twin Pregnancies: A Population‐Based Cohort Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine whether the associations between pre‐pregnancy risk factors and severe preeclampsia/eclampsia (SPE) and/or HELLP syndrome differ between singleton and twin pregnancies. Design A population‐based retrospective cohort study. Setting British Columbia (BC), Canada.
Mackenzie Campbell   +17 more
wiley   +1 more source

Measuring EQ-5D-5L utility values in parents who have experienced perinatal death. [PDF]

open access: yesEur J Health Econ
Camacho EM   +4 more
europepmc   +1 more source

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