Results 51 to 60 of about 299,223 (241)

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Magnitude and Determinants of Adverse Perinatal Outcomes in Tefera Hailu Memorial Hospital, Sekota Town, Northern Ethiopia

Global Pediatric Health, 2021
Background Of 133 million births globally, 3.7 million died in the neonatal period and 3 million are stillborn. The perinatal mortality rate in Ethiopia is 46 per 1000 pregnancies. However, area-specific information is limited in this regard.
Eshetu Seyoum, Alemayehu Bekele, Adino Tesfahun Tsegaye, Simon Birhanu   +3 more
doaj   +1 more source

Influence of perinatal distress on adverse birth outcomes: A prospective study in the Tigray region, northern Ethiopia.

PLoS ONE, 2023
BackgroundIn low-income countries, where socioeconomic adversities and perinatal distress are common, adverse birth outcomes are significant public health problems. In these settings, perinatal distress, i.e., high symptoms of anxiety, depression, and/or
Kebede Haile Misgina, Lindsay Levine, H Marike Boezen, Afework Mulugeta Bezabih, Eline M van der Beek, Henk Groen   +5 more
doaj   +1 more source

Men’s Perinatal Mental Health in the Transition to Fatherhood [PDF]

, 2015
While fathers have come to be more involved with their partners and infants throughout the perinatal period, recent research has shown that roughly 10% of new dads experience mental health difficulties including depression and anxiety. Unfortunately, few
Edwards, Lisa, Singley, Daniel B.
core   +1 more source

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

Inadequate Prenatal Visit and Home Delivery as Determinants of Perinatal Outcomes: Does Parity Matter?

Journal of Pregnancy, 2019
Background. Adverse perinatal outcomes are still high in developing countries. Contradicting evidences were reported about the effect of parity on adverse perinatal outcomes.
Nigus Bililign Yimer, Zelalem Tenaw, Kalkidan Solomon, Tesfahun Mulatu   +3 more
doaj   +1 more source

Secular trends and age-period-cohort effect on adverse perinatal outcomes in Hubei, China (2011–2019)

Scientific Reports, 2022
The increasing trend in the incidence of adverse perinatal outcomes is a public health concern globally as well as in China. However, the causes of the increasing trend are not well understood.
Hui Li, Yuanmei Shi, Zahoor Ahmed, Abbas khan, Kang Xu, Xiaoping Yin, Nawsherwan, Hong Zhang   +7 more
doaj   +1 more source

“And in some cases, we're the best option:” A qualitative study of community‐based doula support for black perinatal mental health

American Journal of Community Psychology, EarlyView.
Abstract We explored community‐based doulas' perspectives on the acceptability of using formal screening tools to address low rates of mental health screening, diagnosis, and treatment for perinatal anxiety and depression among Black women. Using thematic analysis, we analyzed interview data from 30 community‐based doulas who support Black families ...
Tamara Nelson, Naysha N. Shahid, Samrawit B. Gebretensay, Chareina C. Johnson, Penny D. Telesford, Karen Sheffield‐Abdullah   +5 more
wiley   +1 more source