Results 51 to 60 of about 2,108,691 (209)

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

Pushing the Frontiers: Artificial Intelligence (AI)‐Guided Programmable Concepts in Binary Self‐Assembly of Colloidal Nanoparticles

open access: yesAdvanced Science, Volume 12, Issue 28, July 24, 2025.
Colloidal nanoparticles self‐assembly advances towards intelligent, customized assembly through precise control of binary co‐assemblies. This review explores the evolution from monolithic to binary assemblies, highlighting how the AI‐guided programmable assembly approach has the potential to shift from passive assembly to active intelligent design.
Cancan Li   +5 more
wiley   +1 more source

The short-term impact of the alcohol act on alcohol-related deaths and hospital admissions in Scotland: a natural experiment [PDF]

open access: yes, 2018
Background and aim: The introduction of the Alcohol Act in Scotland on 1 October 2011, which included a ban on multi-buy promotions, was likely associated with a fall in off-trade alcohol sales in the year after its implementation.
Babor   +31 more
core   +1 more source

Critical Electrochemistry Technologies Applicable in Space Exploration

open access: yesAdvanced Science, EarlyView.
The available resources in space and discuss the application scenarios and challenges of electrochemical methods in four critical domains is analyzed: metallurgical processing of mineral resources, water resources utilization, carbon cycle management in extraterrestrial habitats, and electrical energy storage.
Ruisi Xu   +4 more
wiley   +1 more source

Review of medicine registration system in Tanzania [PDF]

open access: yes, 2019
Philosophiae Doctor - PhDRegistration of medicines is an essential function of the national medicine regulatory system of any country. Since the start of the medicine registration system in Tanzania in early 2000s, no systematic review has been carried
KISOMA, SUNDAY
core  

On Midrange Periodicities in Solar Radio Flux and Sunspot Areas

open access: yes, 2018
Using the Hilbert-Huang transform technique, we investigate the midrange periodicities in solar radio flux at 2800 MHz (F10.7) and sunspot areas (SAs) from February 1, 1947 to September 30, 2016.
Deng, Hui, Mei, Ying, Wang, Feng
core   +1 more source

Trends of influenza B during the 2010–2016 seasons in 2 regions of north and south Italy: The impact of the vaccine mismatch on influenza immunisation strategy [PDF]

open access: yes, 2018
Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The 2 viral types often co-circulate and influenza B plays an important role in the spread of infection.
Alicino C.   +9 more
core   +1 more source

Transparent and Transient Flexible Electronics

open access: yesAdvanced Science, EarlyView.
Transparent electronics has gained tremendous attention in recent years because of the growing demand for see‐through devices in applications such as displays, windscreens, and wearables. This review discusses the recent developments related to transparent electronics as well as the challenges associated with the development of flexible and transient ...
Nitheesh M. Nair   +2 more
wiley   +1 more source

Advances in Medical Devices for Augmented Acupuncture Therapy

open access: yesAdvanced Science, EarlyView.
Traditional acupuncture therapy faces several challenges in clinical applications, such as complex operation procedures and prolonged therapeutic periods. By incorporating physical stimulations and drug delivery technologies, engineered acupuncture needles (EANs) can enhance therapeutic efficacy, improve patient compliance, as well as mitigate ...
Ruisi Cai   +7 more
wiley   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

open access: yesAdvanced Science, Volume 12, Issue 28, July 24, 2025.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu   +9 more
wiley   +1 more source

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