Results 121 to 130 of about 766,070 (327)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Variational Methods for Almost Periodic Solutions of a Class of Neutral Delay Equations
Abstract and Applied Analysis, 2008 We provide new variational settings to study the a.p. (almost periodic) solutions of a class of nonlinear neutral delay equations. We extend Shu and Xu (2006) variational setting for periodic solutions of nonlinear neutral delay equation to the ...
M. Ayachi, J. Blot
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On the periodicity of the solution of a certain nonlinear integral equation [PDF]
, 1958 Olavi Hellman
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Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
The Traveling Wave Solutions and Their Bifurcations for the BBM-Like B(m,n) Equations
Journal of Applied Mathematics, 2013 We investigate the traveling wave solutions and their bifurcations for the BBM-like B(m,n) equations ut+αux+β(um)x−γ(un)xxt=0 by using bifurcation method and numerical simulation approach of dynamical systems.
Shaoyong Li, Zhengrong Liu
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Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Exact Solutions of Travelling Wave Model via Dynamical System Method
Abstract and Applied Analysis, 2016 By using the method of dynamical system, the exact travelling wave solutions of the coupled nonlinear Schrödinger-Boussinesq equations are studied. Based on this method, the bounded exact travelling wave solutions are obtained which contain solitary wave
Heng Wang, Longwei Chen, Hongjiang Liu
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On the existence of periodic solutions for certain differential equations [PDF]
, 1953 Shouro Kasahara
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Stability and existence of a periodic solution
Journal of Differential Equations, 1968 Many authors have discussed the existence of a periodic solution of a periodic system of differential equations under the assumption that the system has a bounded solution which has some kind of stability. LaSalle [Z] has discussed a more general case by considering an asymptotic stability property of motions. Hale [2] and the author [3] have discussed
openaire +3 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source