Results 51 to 60 of about 1,146 (216)

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Kernel sections and (almost) periodic solutions of a non-autonomous parabolic PDE with a discrete state-dependent delay

Communications on Pure and Applied Analysis, 2011
In this paper, we consider the long time behavior of a non-autonomous parabolic PDE with a discrete state-dependent delay. We study the existence of compact kernel sections and unique complete trajectory of the corresponding problem. Furthermore, we obtain the (almost) periodic solution which attracts all solutions provided the time dependent
Xiang Li, Zhixiang Li
openaire   +1 more source

Cyclodextrins as Chiral Selectors in Capillary Electrophoresis—Recent Developments in Understanding Analyte Complexation and Applications in Pharmaceutical Analysis

ELECTROPHORESIS, EarlyView.
Cyclodextrins are the most often applied chiral selectors in CE enantioseparations. In combination with NMR spectroscopy and molecular modeling, studies for an understanding of chiral recognition underlying enantioseparations have been performed.
Gerhard K. E. Scriba
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

The Perturbed Chen–Lee–Liu Equation: Diverse Optical Soliton Solutions and Other Wave Solutions

Advances in Mathematical Physics
The objective of the present study is to extract the optical soliton solutions (OSSs) of the perturbed Chen–Lee–Liu equation by exerting three techniques, which are the extended Wang’s direct mapping method, tanh/coth function method and the Subequation ...
Kang-Jia Wang
doaj   +1 more source

Exact soliton solutions, chaotic dynamics, and high-precision simulations for the modified complex Ginzburg–Landau equation [PDF]

AIP Advances
This study presents a unified framework for the modified complex Ginzburg–Landau (CGL) equation, addressing key gaps in traditional research, such as the neglect of coupling between fourth-order dispersion and Kerr nonlinearity, as well as improper ...
Zexian Liu, Peng Guo, Jianming Qi, Guangyang Wang   +3 more
doaj   +1 more source

A direct method for the numerical solution of optimization problems with time-periodic PDE constraints [PDF]

, 2011
In der vorliegenden Dissertation entwickeln wir auf der Basis der Direkten Mehrzielmethode eine neue numerische Methode fur Optimalsteuerungsprobleme (OCPs) mit zeitperiodischen partiellen Differentialgleichungen (PDEs). Die vorgeschlagene Methode zeichnet sich durch asymptotisch optimale Skalierung des numerischen Aufwandes in der Zahl der ortlichen ...
openaire   +1 more source

Existence of weak quasi-periodic solutions for a second order Hamiltonian system with damped term via a PDE approach

Electronic Journal of Qualitative Theory of Differential Equations, 2016
Summary: In this paper, we investigate the existence of weak quasi-periodic solutions for the second order Hamiltonian system with damped term: \[ \ddot{u}(t)+q(t)\dot{u}(t)+D W(u(t))=0, \qquad t\in \mathbb R,\tag{HSD} \] where \(u:\mathbb R\to \mathbb R^n\), \(q:\mathbb R\to \mathbb R\) is a quasi-periodic function, \(W:\mathbb R^n\to \mathbb R\) is ...
Zhang, Xingyong, Wang, Liben
openaire   +3 more sources

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Stability Evaluation and Parametric Optimization of Coal‐Concrete Composite Bearing Systems Under Mine‐Water‐Induced Deterioration: Experiments and FEINN Analysis

Energy Science &Engineering, EarlyView.
Mine‐water immersion tests reveal pronounced coal weakening (vs. minor concrete degradation), identifying coal pillars as the stability‐limiting component in composite dams. A coupled FEINN framework quantifies extreme‐pressure stability and ranks multi‐parameter designs via a normalized multi‐indicator scheme, enabling optimized dam configuration for ...
He Wen, Hongchuan Dai, Guixin Zhang, Pengzhe Li, Tong Yang, Cang Gong, Renbo Gao   +6 more
wiley   +1 more source