Results 81 to 90 of about 2,543,179 (336)

Where Does Chemistry Go? From Mendeelev Table of Elements to the Big Data Era

open access: yesSubstantia, 2019
One hundred and fifty years ago the Russian chemist Dmitri Ivanovich Mendeleev published the first “Periodic System of the Elements” originated to display the periodic trends of the chemical elements known at that time and possibly to predict unknown ...
Luigi Campanella, Laura Teodori
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

AITP 2019 - ANO INTERNACIONAL DA TABELA PERIÓDICA DOS ELEMENTOS QUÍMICOS

open access: yesQuímica Nova
United Nations elected 2019 a year devoted to the Periodic Table of the Elements, in deference to the original contribution by Dmitri Ivanovich Mendeleev in 1869.
Henrique E. Toma
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Flow Disturbance Compensation Based on Off-Line Estimated Signal for a Pneumatic Isolation Table

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
The flow disturbance to a pneumatic vibration isolation table causes periodic fluctuation of the table. In current study, one cycle of flow disturbance is estimated offline using a disturbance observer.
Habiburahman SHIRANI   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The Development of the Periodic Table and its Consequences

open access: yesSubstantia, 2019
Chemistry is fortunate among the sciences in having an icon that is instantly recognisable around the world: the periodic table. The United Nations has deemed 2019 to be the International Year of the Periodic Table, in commemoration of the 150th ...
John Emsley
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

O ano internacional da tabela periódica e o ensino de química: das cartas ao digital

open access: yesQuímica Nova
Proclaimed by UNESCO the International Year of the Periodic Table of Chemical Elements in 2019 (IYPT 2019) will commemorate a remarkable series of important milestones in the history of the periodic table of chemical elements.
Bruno S. Leite
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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