Results 261 to 270 of about 3,822 (305)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Characterization of Conformational Instability of Monoclonal Antibodies During Chromatographic Purification. [PDF]

Int J Mol Sci
Baran K, Podgórski R.
europepmc   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Floquet engineering of Feshbach resonances in ultracold gases. [PDF]

Sci Adv
Guthmann A, Lang F, Kienesberger LM, Barbosa S, Widera A.   +4 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

B₀ navigator enables respiratory motion navigation in radial stack-of-stars liver Look-Locker T₁ mapping. [PDF]

Magn Reson Med
Stelter J, Weiss K, Spieker V, Schnabel JA, Braren RF, Karampinos DC.   +5 more
europepmc   +1 more source

Star Power: Early life stages of an endangered sea star are robust to current and near-future warming. [PDF]

PLoS One
Hodin J, Anteau FP, Ashcraft BF, Brito M, Curliss F, Kalytiak-Davis AR, Peng JS, Schwab CJ, Valdez VV, Weertman W.   +9 more
europepmc   +1 more source

Observations of variable stars of long period

The Astronomical Journal, 1896
openaire   +1 more source

Multi-scale parameterization of neural rhythmicity with lagged Hilbert autocoherence. [PDF]

Imaging Neurosci (Camb)
Zhang S, Szul MJ, Papadopoulos S, Massera A, Rayson H, Bonaiuto JJ.   +5 more
europepmc   +1 more source

Dose-Dependent Efficacy of a Riboflavin and Ultraviolet Light-Inactivated Whole-Virion SARS-CoV-2 Vaccine in a Hamster Infection Challenge Model. [PDF]

Vaccines (Basel)
Altina N, Ragan IK, Arnett KA, Jones S, Glass A, Dutt TS, Obregon-Henao A, Maldonado P, Harris M, Bowen RA, Kruh-Garcia N, Heaslip D, Yonemura S, Henao-Tamayo M, Goodrich RP.   +14 more
europepmc   +1 more source