Results 71 to 80 of about 15,006,822 (290)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Periodical Press in Alytus in 1920-1940

Knygotyra
The first newspapers in Alytus were produced in a manuscript form. This kind of publications was popular among students after the World War l. Alytus was not an exception.
Šarūnas Šimkevičius
doaj   +3 more sources

Review of Giuliana Elena Garzone, Mara Logaldo and Francesca Santulli, eds, Investigating Conflict Discourses in the Periodical Press (2020)

Journal of European Periodical Studies, 2022
Review of Giuliana Elena Garzone, Mara Logaldo and Francesca Santulli, eds, Investigating Conflict Discourses in the Periodical Press (2020)
doaj   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

THE DISCUSSION IN THE PRESS OF THE SECOND HALF OF THE 19TH CENTURY ABOUT THE PLACE AND ROLE OF THE RUSSIAN ORTHODOX CHURCH IN THE PUBLIC LIFE OF POST-REFORM RUSSIA

Известия высших учебных заведений. Поволжский регион: Гуманитарные науки, 2020
Background. A study of the materials of the periodical press of the capital and the province in relation to the status of the Russian Orthodox Church in the second half of the 19th – early 20th centuries allow us to understand the position of ...
N. G. Karnishina
doaj   +1 more source

The image of the Baltic States in Russian periodical press in context of geopolitical changes (1991-2009). [PDF]

, 2016
In dissertation is made analyse of the Baltic States image in Russian periodical press in context of geopolitical ...
Denisenko, Viktor,
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Review of Megan Coyer, Literature and Medicine in the Nineteenth-Century Periodical Press: Blackwood’s Edinburgh Magazine, 1817–1858 (2017)

Journal of European Periodical Studies, 2019
Review of Megan Coyer, Literature and Medicine in the Nineteenth-Century Periodical Press: Blackwood’s Edinburgh Magazine, 1817–1858 (2017)
Jolien Gijbels
doaj   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source