Results 141 to 150 of about 9,101,177 (365)

Targeting keystone species helps restore the dysbiosis of butyrate‐producing bacteria in nonalcoholic fatty liver disease

iMeta, Volume 1, Issue 4, December 2022., 2022
In this study, we applied an algorithm to the keystone species identification in the gut microbiome, based on current causal inference theories and the dynamic intervention simulation. We identified the nonalcoholic steatohepatitis (NASH) keystone species combination, represented by Porphyromonas loveana, Alistipes indistinctus, and Dialister ...
Dingfeng Wu, Lei Liu, Na Jiao, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu, Rohit Loomba, Ruixin Zhu   +9 more
wiley   +1 more source

Supra- and Subgingival Microbiome in Gingivitis and Impact of Biofilm Control: A Comprehensive Review

Antibiotics
This comprehensive review aimed (1) to characterize the sub- and supragingival microbiome in patients with biofilm-induced gingivitis (including experimental gingivitis), (2) to assess its stability and evolution over time, and (3) to assess the impact ...
Margarita Iniesta, Viviane Vasconcelos, Mariano Sanz, David Herrera   +3 more
doaj   +1 more source

Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study

International Journal of Cancer, 2016
Some studies suggest that periodontal diseases increase the risk of oral cancer, but contradictory results also exist. Inadequate control of confounders, including life course exposures, may have influenced prior findings. We estimate the extent to which
C. Laprise, H. Shahul, S. Madathil, A. ThekkePurakkal, G. Castonguay, I. Varghese, Shameena Shiraz, P. Allison, N. Schlecht, M. Rousseau, E. Franco, B. Nicolau   +11 more
semanticscholar   +1 more source

Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA)–associated anticitrullinated protein antibodies (ACPAs) target various antigens by binding short citrulline amino acid motifs, resulting in heterogeneous ACPA profiles among patients. Here we analyzed ACPA patterns by recognized citrulline motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE) alleles
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Johan Askling, Caroline Grönwall   +18 more
wiley   +1 more source

A Low-Cost Protocol Using the Adjunctive Action of Povidone–Iodine Irrigations and Sodium Hypochlorite Rinsing Solution in Step 2 of Periodontal Therapy for Patients with Stage III–IV Periodontitis: A Single-Blind, Randomized Controlled Trial

Dentistry Journal
In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral and bacterial etiology; thus, a mechanical approach alone may not be sufficient to eliminate a substantial portion of ...
Georgios Kardaras, Ruxandra Christodorescu, Marius Boariu, Darian Rusu, Alla Belova, Salvatore Chinnici, Octavia Vela, Viorelia Radulescu, Simina Boia, Stefan-Ioan Stratul   +9 more
doaj   +1 more source

Bayesian Nonparametric Policy Search with Application to Periodontal Recall Intervals [PDF]

arXiv, 2018
Tooth loss from periodontal disease is a major public health burden in the United States. Standard clinical practice is to recommend a dental visit every six months; however, this practice is not evidence-based, and poor dental outcomes and increasing dental insurance premiums indicate room for improvement.
arxiv  

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

BAREB: A Bayesian repulsive biclustering model for periodontal data [PDF]

arXiv, 2019
Preventing periodontal diseases (PD) and maintaining the structure and function of teeth are important goals for personal oral care. To understand the heterogeneity in patients with diverse PD patterns, we develop BAREB, a Bayesian repulsive biclustering method that can simultaneously cluster the PD patients and their tooth sites after taking the ...
arxiv  

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

JBMR Plus, Volume 7, Issue 1, January 2023., 2023
ABSTRACT Hypophosphatasia (HPP), caused by loss‐of‐function mutations in the ALPL gene encoding tissue‐nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life‐threatening to milder manifestations only in adulthood.
Flavia Amadeu de Oliveira, Fatma F. Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan   +7 more
wiley   +1 more source