Results 61 to 70 of about 328,498 (380)

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Thermoresponsive Azithromycin-Loaded Niosome Gel Based on Poloxamer 407 and Hyaluronic Interactions for Periodontitis Treatment

Pharmaceutics, 2022
Azithromycin (AZM) is a potential antimicrobial drug for periodontitis treatment. However, a potential sustained-release system is needed for intra-periodontal pocket delivery.
Kunchorn Kerdmanee, Thawatchai Phaechamud, Sucharat Limsitthichaikoon   +2 more
doaj   +1 more source

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

A novel single-step surgical technique for vestibular deepening using laser in conjunction with periodontal flap surgery

Journal of Indian Society of Periodontology, 2016
Moderate-to-severe chronic periodontitis results in clinical loss of attachment, reduced width of attached gingiva (AG), periodontal pockets beyond mucogingival junction (MGJ), gingival recession, loss of alveolar bone, and decreased vestibular depth (VD)
Ashu Bhardwaj, Nishat Sultan, Madhuri Sawai, Zeba Jafri   +3 more
doaj   +1 more source

Influence of Periodontitis, Implant, and Prosthesis Characteristics on the Peri-Implant Status: A Cross-Sectional Study

International Journal of Dentistry, 2022
Background. The association between peri-implant diseases and the periodontal, implant, and prosthesis characteristics has been characterized in various ways. Purpose.
Ioanna Papalou, Panagiota Vagia, Ahmet Cakir, Henri Tenenbaum, Olivier Huck, Jean-Luc Davideau   +5 more
doaj   +1 more source

Analyzing Equivalency and Accuracy of Three Different Periodontal Probes in Measuring Pocket Depth – An In-Vitro Study

Journal of the California Dental Association, 2023
Background The periodontal probe is an essential instrument designed for the purposes of recording clinical periodontal data. As such, accurate periodontal measurements remain a critical factor in providing individualized care to patients. The purpose of
Rachel Koh, Sharon Lee, Udochukwu Oyoyo, So Ran Kwon, Nima D. Sarmast   +4 more
doaj   +1 more source

Probiotic Biotherapy: Discussing its Influential Role in Oral Health [PDF]

, 2020
Introduction: Probiotics are widely known for their health promoting benefits, especially with its association to gastrointestinal health. For many years, most research has been focused on the prevention or treatment of gastrointestinal infections or ...
Florez, Karla, Sullano, Claudette
core   +1 more source

Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients [PDF]

, 2015
Aim: To investigate the chemotactic accuracy of peripheral blood neutrophils from patients with chronic periodontitis compared with matched healthy controls, before and after non-surgical periodontal therapy.
Agarwal, Andrew, Bagorda, Berridge, Biemond, Bostan, Brock, Cedergren, Champagne, Chapple, Chapple, Chapple, Choi, Clark, Cooper, Cotter, Daniel, Dias, Dias, Dias, Dickinson, Dietrich, Dyke, Dyke, Dyke, Dyke, Dyke, Fu, Fujita, Gamonal, Graves, Grossi, Haastert, Harvath, Henry, Herlihy, Herlihy, Kantarci, Kaul, Kolaczkowska, Kuiper, Kumar, Kurihara, Lakshman, Lambeth, Lavine, Matthews, Matthews, Miesel, Mizuno, Muinonen-Martin, Nibali, Niethammer, Nishizuka, Offenbacher, Pablo, Page, Partida-Sanchez, Phillips, Rahman, Sackmann, Samanta, Sapey, Toker, Tsai, Tyagi, Van Dyke, Wells, Worthen, Wright, Yagi, Yoshikawa, Zigmond   +72 more
core   +2 more sources

Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation

Advanced Science, EarlyView.
TPP‐SAT, a mitochondria‐targeted natural enzyme‐cascade nanogel, selectively scavenges mitochondrial ROS (e.g., H2O2/·O2⁻) and converts them into therapeutic O2 via enzymatic cascades, alleviating hypoxia and inflammation. It rebalances M1/M2 macrophage polarization, activates the Nrf2 pathway while suppressing NF‐κB, enhances antioxidant defenses, and
Yanfen Zheng, Liuzhou Mao, Qi Wang, Haohua Hu, Bahriman Xarpidin, Zheng Luo, Yun‐Long Wu   +6 more
wiley   +1 more source

Aloe vera: A Multipurpose Healer and Bacterial Eradicator [PDF]

, 2018
The Aloe vera plant is a succulent known for its rich content in vitamins and minerals, thus gaining popularity over the years in healthcare products.
Blackburn, Linda K, Jimenez, Leira N, Tran, Mary X   +2 more
core   +1 more source