Results 101 to 110 of about 861,223 (383)

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects

Bioengineering, 2022
The regeneration of periodontium represents important challenges to controlling infection and achieving functional regeneration. It has been recognized that tissue engineering plays a vital role in the treatment of periodontal defects, profiting from ...
Siyang Chen, Xin Huang
doaj   +1 more source

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
Akiyama, Alharbi, Armitage, Armitage, Armitage, Balin, Barbieri, Bergdahl, Berliner, Borilova Linhartova, Borrell-Pages, Bowling, Braak, Braak, Brown, Bu, Buchanan, Burt, Cambell, Cavrini, Chiu, Chukkapalli, Chukkapalli, Chukkapalli, Cole, Corder, Corrada, Curtiss, Cutler, De Oliveira, DeFronzo, DeStefano, Desvarieux, Duarte, Epel, Farrer, Forner, Foster, Freitag-Wolf, Galbraith, Gan, Gao, Genco, Grehan, Grossi, Habib, Haffajee, Hajishengalis, Hajishengalis, Haraszthy, Hardardottir, Hardy, Harold, Harper, Hayashi, Hayden, Heiduschka, Helfand, Het, Hitt, Holt, Hu, Huang, Hunter, Hutton, Imhof, Iqbal, Itzhaki, Jagannathachary, Joiner, Kamer, Kamer, Kamer, Katz, Khovidhunkit, Klein, Kliegel, Kolovou, Kornman, Kozarov, Kubota, Lalla, Lambert, Lesne, Leszcynska, Libby, Machado, Mahley, Mahley, Mahley, Mahley, Maney, Marti, McGeer, Michalowicz, Miklossy, Miklossy, Miller, Mooradian, Moutsopoulos, Nagpal, Neto, Nicoll, Noble, Okuda, Olsen, Ono, O’Brien, Papapanou, Perls, Pitas, Pizzo, Poirier, Poling, Poole, Poole, Rivera, Riviere, Rogers, Rohn, Roses, Roses, Rowe, Saito, Saunders, Scannapieco, Schuett, Shao, Singhrao, Singhrao, Singhrao, Singhrao, Small, Smit, Socransky, Soscia, Stein, Strittmatter, Strittmatter, Sullivan, Velsko, Walsh, Walsh, Watkins, Weisgraber, Wetterau, Wilson, Young   +147 more
core   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Antimicrobial Efficacy and Soft-Tissue Safety of Air-Polishing Powders in Periodontal Therapy: A Narrative Review

Journal of Functional Biomaterials
Periodontitis is a biofilm-induced multifactorial disease characterized by non-reversible damage of the periodontal tissues. Dysbiosis of the subgingival microbiota plays a crucial role in periodontitis. In this regard, conventional periodontal treatment
Ștefania Sorina Ifrim, Alina Bârdea, Alexandra Roman, Andrada Soancă, Silviu Albu, Anda Gâta, Carmen Silvia Caloian, Andreea Cândea   +7 more
doaj   +1 more source

Performance of mesenchymal cell-scaffold constructs in human oral reconstructive surgery: a systematic review [PDF]

, 2016
Background: Different sources of cultured cells combined with different scaffolds (allogenic, xenogeneic, alloplastic or composite materials) have been tested extensively in vitro and in preclinical animal studies, but there have been only a few ...
ANNIBALI, Susanna, Cristalli, Maria Paola, LA MONACA, Gerardo, MARINI, ROBERTA, Patini, Romeo, PRANNO, NICOLA   +5 more
core   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

A novel toothbrush with a thin-head, slender-neck and super-tapered bristles enhancing accessibility in hard-to-reach areas: a crossover randomized trial

BMC Oral Health
Background Toothbrushing is the most commonly used method to physically remove dental plaque. However, there are many areas of the mouth that are difficult to reach with a toothbrush.
Hyo-Jung Kim, Joo-Yeon Lee, Eun-Song Lee, Da-Mi Kim, Ui-Won Jung, Jae-Kook Cha, Baek-Il Kim   +6 more
doaj   +1 more source

Decellularized human periodontal ligament for periodontium regeneration.

PLoS ONE, 2019
Regenerating the periodontal ligament (PDL) is a crucial factor for periodontal tissue regeneration in the presence of traumatized and periodontally damaged teeth.
Hyoju Son, Mijeong Jeon, Hyung-Jun Choi, Hyo-Seol Lee, Ik-Hwan Kim, Chung-Min Kang, Je Seon Song   +6 more
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source