Results 1 to 10 of about 748,441 (391)

Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer.

New England Journal of Medicine, 2023
BACKGROUND Among patients with resectable early-stage non-small-cell lung cancer (NSCLC), a perioperative approach that includes both neoadjuvant and adjuvant immune checkpoint inhibition may provide benefit beyond either approach alone.
H. Wakelee, M. Liberman, T. Kato, M. Tsuboi, Se-Hoon Lee, Shugeng Gao, Keke Chen, C. Dooms, M. Majem, E. Eigendorff, G. Martinengo, O. Bylicki, D. Rodríguez-Abreu, J. Chaft, S. Novello, Jing Yang, S. Keller, A. Samkari, J. Spicer   +18 more
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Perception of feeling safe perioperatively: a concept analysis

International Journal of Qualitative Studies on Health & Well-Being, 2023
Purpose The purpose of this study was to explore the concept of feeling safe, from the patient perspective, in a perioperative context. Method The eight-step concept analysis approach proposed by Walker and Avant was utilized to examine the attributes of
Fanny Larsson, Ulrica Strömbäck, Silje Rysst Gustafsson, Åsa Engström   +3 more
doaj   +1 more source

Perioperative Durvalumab for Resectable Non-Small-Cell Lung Cancer.

New England Journal of Medicine, 2023
BACKGROUND Neoadjuvant or adjuvant immunotherapy can improve outcomes in patients with resectable non-small-cell lung cancer (NSCLC). Perioperative regimens may combine benefits of both to improve long-term outcomes.
J. Heymach, David H. Harpole, Tetsuya Mitsudomi, Janis M. Taube, Gabriella Gálffy, Maximilian Hochmair, Thomas Winder, R. Zukov, Gabriel Garbaos, Shugeng Gao, Hiroaki Kuroda, G. Ostoros, Tho V Tran, Jian You, Kang-Yun Lee, L. Antonuzzo, Z. Pápai-Székely, Hiroaki Akamatsu, Bivas Biswas, A. Spira, Jeffrey Crawford, Ha T Le, M. Aperghis, Gary J. Doherty, Helen Mann, T. Fouad, M. Reck   +26 more
semanticscholar   +1 more source

Transforming Standard of Care for Spine Surgery: Integration of an Online Single-Session Behavioral Pain Management Class for Perioperative Optimization

Frontiers in Pain Research, 2022
Estimates suggest that 10-40% of lumbar spine surgery patients experience persistent post-surgical pain (PPSP). PPSP is associated with 50% greater healthcare costs, along with risks of emotional distress and impaired quality of life.
Sara A. Davin, Jason Savage, Nicholas R. Thompson, Andrew Schuster, Beth D. Darnall   +4 more
doaj   +1 more source

Drug Utilization for Pain Management during Perioperative Period of Total Knee Arthroplasty in China: A Retrospective Research Using Real-World Data

Medicina, 2021
Background and Objective: Total knee arthroplasty (TKA) is one of the most painful procedures and perioperative pain usually requires the use of many analgesics to relieve it.
Xianwen Chen, Lisong Yang, Xueli Liu, He Zhu, Fei Yu, Carolina Oi Lam Ung, Hao Hu, Waisin Chan, Honghao Shi, Sheng Han   +9 more
doaj   +1 more source

Evaluation of a behavioural intervention to reduce perioperative midazolam administration to older adults

BJA Open, 2023
Background: Older patients commonly receive benzodiazepines during anaesthesia despite guidelines recommending avoidance. Interventions to reduce perioperative benzodiazepine use are not well studied.
Scott Seki, Molly Candon, Sushila Murthy, Gurmukh Sahota, Rachel R. Kelz, Mark D. Neuman   +5 more
doaj   +1 more source

ASRA Pain Medicine consensus guidelines on the management of the perioperative patient on cannabis and cannabinoids

Regional anesthesia and pain medicine, 2023
Background The past two decades have seen an increase in cannabis use due to both regulatory changes and an interest in potential therapeutic effects of the substance, yet many aspects of the substance and their health implications remain controversial ...
Shalini Shah, E. Schwenk, R. Sondekoppam, Hance Clarke, M. Zakowski, Rachel S Rzasa-Lynn, Brent G Yeung, Kate M Nicholson, Gary Schwartz, W. M. Hooten, M. Wallace, E. Viscusi, S. Narouze   +12 more
semanticscholar   +1 more source

PD-1 blockade attenuates surgery-mediated immunosuppression and boosts Th1 immunity perioperatively in oesophagogastric junctional adenocarcinoma

Frontiers in Immunology, 2023
IntroductionThis timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal cancer ...
Maria Davern, Maria Davern, Caoimhe Gaughan, Fiona O’ Connell, Brendan Moran, Eimear Mylod, Andrew D. Sheppard, Sinead Ramjit, Jasmine Yun-Tong Kung, James J. Phelan, Matthew G. Davey, Eanna J. Ryan, Christine Butler, Laura Quinn, Claudine Howard, Emily Tone, Eimear Phoenix, Waqas T. Butt, Niamh Lynam-Lennon, Stephen G. Maher, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Noel E. Donlon   +24 more
doaj   +1 more source

Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial.

JAMA Oncology, 2021
Importance Clinical outcomes after curative treatment of resectable pancreatic ductal adenocarcinoma (PDA) remain suboptimal. To assess the potential of early control of systemic disease with multiagent perioperative chemotherapy, we conducted a ...
D. Sohal, M. Duong, Syed A. Ahmad, N. Gandhi, M. Beg, A. Wang-Gillam, J. Wade, E. Chiorean, K. Guthrie, A. Lowy, P. Philip, H. Hochster   +11 more
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Perioperative neurocognitive disorders: A narrative review focusing on diagnosis, prevention, and treatment

CNS Neuroscience & Therapeutics, 2022
Perioperative neurocognitive disorders (NCDs) refer to neurocognitive abnormalities detected during the perioperative periods, including preexisting cognitive impairment, preoperative delirium, delirium occurring up to 7 days after surgery, delayed ...
H. Kong, Long-Ming Xu, Dong-Xin Wang
semanticscholar   +1 more source