Results 61 to 70 of about 535,114 (342)

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

open access: yesAdvanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi   +8 more
wiley   +1 more source

Influence of Esophageal Endoscopic Submucosal Dissection on the Changes of Energy Metabolism during the Perioperative Period [PDF]

open access: gold, 2022
Sae Kudo   +18 more
openalex   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu   +6 more
wiley   +1 more source

Reducing gastrointestinal anastomotic leak rates: Review of challenges and solutions [PDF]

open access: yes, 2016
Various techniques and interventions have been developed in an effort to obviate gastrointestinal anastomotic leaks. This review is intended to delineate potential modifications that can be made to reduce the risk of anastomotic leaks following ...
Philllips, Benjamin
core   +4 more sources

Perioperative stroke [PDF]

open access: yesCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 2015
Perioperative stroke is associated with significant morbidity and mortality, with an incidence that may be underappreciated. In this review, we examine the significance, pathophysiology, risk factors, and evidence-based recommendations for the prevention and management of perioperative stroke.This is a narrative review based on literature from the ...
Phillip, Vlisides, George A, Mashour
openaire   +2 more sources

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

open access: yesAdvanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger   +17 more
wiley   +1 more source

Parathyroid Hormone Fluctuations During Thyroid and Parathyroid Surgery

open access: yesOTO Open
Objective Stress hormone levels such as cortisol and epinephrine increase with general anesthesia (GA) and surgery. Parathyroid hormone (PTH) has been shown to increase with GA in those undergoing parathyroidectomy (PT) with abnormal parathyroid function,
Emily S. Sagalow   +3 more
doaj   +1 more source

Proposal for Perioperative Pharmacological Protocol for the Reduction in Early Complications in Orthorhinoseptoplasty: Five Years of Experience [PDF]

open access: gold, 2023
Riccardo Nocini   +5 more
openalex   +1 more source

Perioperative genomics [PDF]

open access: yesBest Practice & Research Clinical Anaesthesiology, 2011
Since the completion of the Human Genome Project 10 years ago, the world has witnessed an incredible progress in human genetics and genomics.(1) This progress was largely driven by the availability of better, faster and cheaper sequencing technology.(2) While it took more than 10 years and more than 1 billion dollars to complete the Human Genome ...
openaire   +2 more sources

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

open access: yesAdvanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang   +12 more
wiley   +1 more source

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