Results 61 to 70 of about 479,350 (314)

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Randomized controlled trial of intraoperative goal-directed fluid therapy in aerobically fit and unfit patients having major colorectal surgery. [PDF]

, 2012
BACKGROUND: Intraoperative fluid therapy regimens using oesophageal Doppler monitoring (ODM) to optimize stroke volume (SV) (goal-directed fluid therapy, GDT) have been associated with a reduction in length of stay (LOS) and complication rates after ...
Abbas, Bellamy, Brandstrup, Brunkhorst, Bundgaard-Nielsen, Bundgaard-Nielsen, C. Challand, Davies, Dindo, Faiz, Futier, G. Minto, Gan, Giglio, Grocott, Hollowell, J.R. Sneyd, K.B. Hosie, Kehlet, Lees, Lobo, Mills, N. Mellor, Noblett, Older, P.D. Erasmus, Pearse, Powell-Tuck, R. Struthers, Roche, Sanders, Schortgen, Senagore, Shoemaker, Shoemaker, Snowden, Wakeling, Walsh, Wilson   +38 more
core   +2 more sources

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Risk stratification by pre-operative cardiopulmonary exercise testing improves outcomes following elective abdominal aortic aneurysm surgery : a cohort study [PDF]

, 2013
Background: In 2009, the NHS evidence adoption center and National Institute for Health and Care Excellence (NICE) published a review of the use of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAAs).
AR Thompson, BR Baxendale, CP Snowden, DF Reilly, DP Lipkin, DZH Levett, E Kothmann, EL Young, EVAR trial participants, EVAR Trial Participants, H Bengtsson, H Shiels, J Carlisle, JA Franciosa, JD Blankensteijn, JM Prentis, K Henry, K Salatash, K Waxman, KA Eagle, LA Fleisher, N Buck, National Research Ethics Service, P Older, P Older, P Older, PP Goodney, PR Silverstein, R Struthers, RA Hartley, RAP Scott, RR Attia, S Pearson, SM Bauer, SR Finlayson, TB Smith, The UK Small Aneurysm Trial Participants, WC Shoemaker, WL Beaver, WS Aronow   +39 more
core   +2 more sources

Perioperative stroke [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2015
Perioperative stroke is associated with significant morbidity and mortality, with an incidence that may be underappreciated. In this review, we examine the significance, pathophysiology, risk factors, and evidence-based recommendations for the prevention and management of perioperative stroke.This is a narrative review based on literature from the ...
Phillip, Vlisides, George A, Mashour
openaire   +2 more sources

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Parathyroid Hormone Fluctuations During Thyroid and Parathyroid Surgery

OTO Open
Objective Stress hormone levels such as cortisol and epinephrine increase with general anesthesia (GA) and surgery. Parathyroid hormone (PTH) has been shown to increase with GA in those undergoing parathyroidectomy (PT) with abnormal parathyroid function,
Emily S. Sagalow, Yuna Kim, Shirley Wong, Robert C. Wang   +3 more
doaj   +1 more source

Perioperative genomics [PDF]

Best Practice & Research Clinical Anaesthesiology, 2011
Since the completion of the Human Genome Project 10 years ago, the world has witnessed an incredible progress in human genetics and genomics.(1) This progress was largely driven by the availability of better, faster and cheaper sequencing technology.(2) While it took more than 10 years and more than 1 billion dollars to complete the Human Genome ...
openaire   +2 more sources

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Risk Factors of Intraoperative Dysglycemia in Elderly Surgical Patients [PDF]

, 2019
BACKGROUNDː Dysglycemia is associated with adverse outcome including increased morbidity and mortality in surgical patients. Acute insulin resistance due to the surgical stress response is seen as a major cause of so-called stress hyperglycemia. However,
Knaak, Cornelia, Kuenz, Sophia, Kurpanik, Maryam, Lachmann, Gunnar, Mörgeli, Rudolf, Spies, Claudia, Vorderwülbecke, Gerald, Windmann, Victoria, Wollersheim, Tobias   +8 more
core   +1 more source