Results 91 to 100 of about 4,838,067 (407)

Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis

Advanced Science, EarlyView.
Sleep deprivation (SD) exacerbates ligature‐induced periodontitis (LIP) through the trigeminal nerve‐periodontal neuroimmune pathway mediated by the acetylcholinesterase (AChE)‐acetylcholine (ACh)‐α7 nicotinic receptor (α7nAChR) axis. While electroacupuncture (EA) alleviates the condition of LIP combined with SD by activating the α7nAChR.
Kehao Liu, Qi Huang, Mingcong Yang, Ziyu Huang, Kamoran Tuerhong, Yue Zu, Ying Xie, Xuehui Hu, Qianyu Zhang, Ping He, Nannan Huang, Rong Zhang, Yuzhou Li, Sheng Yang   +13 more
wiley   +1 more source

The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study

Intensive Care Medicine Experimental
Background Acute respiratory distress syndrome (ARDS) is characterised by significant morphological heterogeneity. Morphological sub-phenotyping can potentially be used to personalise mechanical ventilation.
Kristin Jona Bjarnadottir, Martin Tovedal, Gaetano Perchiazzi, Miklos Lipcsey, Lucian Covaciu, Magnus von Seth, Rafael Kawati, Mariangela Pellegrini   +7 more
doaj   +1 more source

Characteristics and outcome of traumatic cardiac arrest at a level 1 trauma centre over 10 years in Sweden

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2022
Background Historically, resuscitation in traumatic cardiac arrest (TCA) has been deemed futile. However, recent literature reports improved but varying survival.
Daniel Ohlén, Magnus Hedberg, Paula Martinsson, Erik von Oelreich, Therese Djärv, Malin Jonsson Fagerlund   +5 more
doaj   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

An attenuated rate of leg muscle protein depletion and leg free amino acid efflux over time is seen in ICU long-stayers

Critical Care, 2018
Background There is extensive documentation on skeletal muscle protein depletion during the initial phase of critical illness. However, for intensive care unit (ICU) long-stayers, objective data are very limited.
Lena Gamrin-Gripenberg, Martin Sundström-Rehal, Daniel Olsson, Jonathan Grip, Jan Wernerman, Olav Rooyackers   +5 more
doaj   +1 more source

Anesthesia Preoperative Clinic Referral for Elevated Hba1c Reduces Complication Rate in Diabetic Patients Undergoing Total Joint Arthroplasty [PDF]

, 2015
Background: Diabetes mellitus (DM) is risk factor for complications after orthopedic surgery. Objectives: We tested the hypothesis that anesthesia preoperative clinic (APC) referral for elevated glycosylated hemoglobin (HbA1c) reduces complication rate ...
Breakwell, Susan, Kallio, Peter J., Nolan, Jenea, Olsen, Amy C., Pagel, Paul S., Topp, Richard   +5 more
core   +2 more sources

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

Post-trauma morbidity, measured as sick leave, is substantial and influenced by factors unrelated to injury: a retrospective matched observational cohort study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2017
Background Mortality as an endpoint has been the focus of trauma research whereas few studies investigate long-term outcomes in terms of morbidity. An adequate analysis of post-injury morbidity includes several dimensions, for this reason sick leave has ...
Erik von Oelreich, Mikael Eriksson, Olof Brattström, Andrea Discacciati, Lovisa Strömmer, Anders Oldner, Emma Larsson   +6 more
doaj   +1 more source

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)

Annals of Intensive Care, 2020
Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance.
M. Malbrain, T. Langer, D. Annane, L. Gattinoni, Paul W. G. Elbers, R. Hahn, I. D. De laet, A. Minini, A. Wong, C. Ince, D. Muckart, M. Mythen, P. Caironi, N. Van Regenmortel   +13 more
semanticscholar   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

Advanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng   +9 more
wiley   +1 more source