Results 261 to 270 of about 134,072 (327)

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, EarlyView.
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong, Xintong Xie, Juan Wu, Xiangyu Wang, Wenxiang Zhang, Shuowen Wang, Daria Valerievna Abbasova, Yi Fang, Hongnan Jiang, Jidong Gao, Jing Wang   +10 more
wiley   +1 more source

Artificial Intelligence: Promise or Pitfalls? A Clinical Vignette of Real-Life ChatGPT Implementation in Perioperative Medicine. [PDF]

J Gen Intern Med
Ha LT, Kelley KD.
europepmc   +1 more source

Novel Transthoracic Pulmonary Valve Implantation Using Self‐Expanding Salus Valve: A Prospective Study of Safety and Mid‐Term Outcomes

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter pulmonary valve replacement (TPVR) has emerged as a valuable treatment for severe pulmonary regurgitation (PR). The Salus valve (Balance Medical Technology Co. Ltd., Beijing, China) represents a novel self‐expanding valve stent designed for deployment through a transthoracic approach with a small subxiphoid incision ...
Ziqin Zhou, Miao Tian, Jiazichao Tu, Yong Zhang, Jian Zhuang, Shusheng Wen, Jimei Chen   +6 more
wiley   +1 more source

Hybrid Transcatheter Pulmonary Valve Replacement With SAPIEN S3 Following Right Ventricular Outflow Tract Reduction Using Tricuspid Annuloplasty Rings

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT We describe a novel variation of hybrid TPVR using a tricuspid annuloplasty ring which can be considered for patients with very large RVOT, short pulmonary artery, and limited vascular access and to avoid the risk of cardiopulmonary bypass. The utilization of Carpentier‐Edwards Physio Tricuspid annuloplasty ring can reduce the size of the RVOT
Mann Chandavimol, Piya Samankatiwat, Alisa Limsuwan, Tawai Ngernsritrakul, Jamil Aboulhosn   +4 more
wiley   +1 more source

Modern perioperative medicine - past, present, and future. [PDF]

Innov Surg Sci, 2019
Dean HF, Carter F, Carter F, Francis NK.
europepmc   +1 more source

GDF15 Analogues Acting as GFRAL Ligands

ChemMedChem, EarlyView.
Considering the great importance of the GDF15/GRAL/RET signalling pathway, this review focuses on GDF15‐derived analogues able to act either as GFRAL agonists or antagonists, investigating their possible pharmacological applications in the treatment of GDF15‐related conditions, such as obesity and diabetes (agonist), or cancer‐induced nausea and ...
Andrea Di Santo, Livio Tarchi, Gianluca Villa, Giovanni Castellini, Valdo Ricca, Roberta Squecco, Anna Maria Papini, Feliciana Real‐Fernandez, Paolo Rovero   +8 more
wiley   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

Perioperative medicine - a vital but neglected part of success in surgery. [PDF]

Innov Surg Sci, 2019
Schwenk W, Freys SM.
europepmc   +1 more source

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli, Sook Wah Yee, Jia Yang, Claire M. Brett, Kelsey Trumbach, Xujia Zhou, Renmeng Liu, Xiaomin Liang, Yurong Lai, Runlan Huo, Yongjun Xue, Hong Shen, Lei Zhang, Xinning Yang, Qi Liu, Shiew‐Mei Huang, Kathleen M. Giacomini   +16 more
wiley   +1 more source

The Drug Titration Paradox Updated and Reinterpreted: With Perfect Titration, Dose and Effect Will Be Uncorrelated

Clinical Pharmacology &Therapeutics, EarlyView.
The drug titration paradox is a clinical observation at a population level whereby patients receiving a high dose of medication appear to have a lower‐than‐average clinical effect, and patients receiving a low dose of medication appear to have a higher‐than‐average clinical effect.
Elie Sarraf, Klaske van Heusden
wiley   +1 more source