Results 21 to 30 of about 271,705 (265)

Hybrid Magnetoactive Soft Elastomers: Material Development Toward Application in Diaphragm Pumps

Advanced Materials Technologies, EarlyView.
Hybrid magnetoactive soft elastomeric membranes are developed by combining two different types of magnetic particles. The membranes exhibit distinct mechanical, magnetic and thermal properties owing to the unique characteristics of the two magnetic particles.
Somashree Mondal, Paweł Orkisz, Bogdan Sapiński, Ralph Spolenak, Frank Clemens   +4 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Safety of overlapping inpatient orthopaedic surgery: A multicenter study [PDF]

, 2018
BackgroundAlthough overlapping surgery is used to maximize efficiency, more empirical data are needed to guide patient safety. We conducted a retrospective cohort study to evaluate the safety of overlapping inpatient orthopaedic surgery, as judged by the
Dy, Christopher J, Gottschalk, Michael B, Maak, Travis G, Maloney, Michael D, O\u27Keefe, Regis J, Osei, Daniel A, Presson, Angela P, Zhang, Alan L   +7 more
core   +1 more source

Laparoscopic versus open radical prostatectomy in high prostate volume cases: impact on oncological and functional results [PDF]

, 2016
To prospectively compare the laparoscopic versus open approach to RP in cases with high prostate volume and to evaluate a possible diferente impact of prostate ...
Andrea, Fasulo, CATTARINO, SUSANNA, Francesca, Di Quilio, GENTILE, Vincenzo, GENTILUCCI, ALESSANDRO, INNOCENZI, MICHELE, SALCICCIA, STEFANO, SCIARRA, Alessandro, VON HELAND, Magnus   +8 more
core   +1 more source

Association of Overlapping Surgery With Perioperative Outcomes [PDF]

JAMA, 2019
Overlapping surgery, in which more than 1 procedure performed by the same primary surgeon is scheduled so the start time of one procedure overlaps with the end time of another, is of concern because of potential adverse outcomes.To determine the association between overlapping surgery and mortality, complications, and length of surgery.Retrospective ...
Sun, Eric, Mello, Michelle M., Rishel, Chris A., Vaughn, Michelle T., Kheterpal, Sachin, Saager, Leif, Fleisher, Lee A., Damrose, Edward J., Kadry, Bassam, Jena, Anupam B., Kooij, Fabian, Wilczak, Janet, Soto, Roy, Berris, Joshua, Price, Zachary, Urman, Richard D., Lins, Steven, Harris, John M., Cummings, Kenneth C., Berman, Mitchell F., Nanamori, Masakatsu, Adelman, Bruce T., Wedeven, Christopher, Bittner, Edward A., LaGorio, John, McCormick, Patrick J., Tom, Simon, Aziz, Michael F., Coffman, Traci, Ellis, Terri A., Molina, Susan, Peterson, William, Mackey, Sean C., van Klei, Wilton A., Mahajan, Aman, Jameson, Leslie C., Biggs, Daniel A., Neuman, Mark D., Craft, Robert M., Pace, Nathan L., Paganelli, William C., Durieux, Marcel E., Nair, Bala J., Wanderer, Jonathan P., Miller, Scott A., Helsten, Daniel L., Turnbull, Zachary A., Kooij, Fabian, Schonberger, Robert B.   +48 more
openaire   +4 more sources

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Designing the ideal perioperative pain management plan starts with multimodal analgesia. [PDF]

, 2018
Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects ...
Mariano, Edward R., Schwenk, Eric S.
core   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Changing clinical and therapeutic trends in tentorial dural arteriovenous fistulas: a systematic review [PDF]

, 2015
BACKGROUND AND PURPOSE: Tentorial dural arteriovenous fistulas are characterized by a high hemorrhagic risk. We evaluated trends in outcomes and management of tentorial dural arteriovenous fistulas and performed a meta-analysis evaluating clinical and ...
Brinjikji, W., Cannizzaro, Delia, Lanzino, G., Murad, M. H., Rammos, S.   +4 more
core   +2 more sources

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source