Results 161 to 170 of about 927,140 (352)
Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation
Advanced Science, EarlyView.Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao +12 morewiley +1 more sourceOptimal management of infrainguinal arterial occlusive disease
Vascular Health and Risk Management, 2014 David J Pennywell, Tze-Woei Tan, Wayne W Zhang Division of Vascular and Endovascular Surgery, Louisiana State University Health Shreveport, Shreveport, LA, USA Abstract: Peripheral arterial occlusive disease is becoming a major health problem in Western Pennywell DJ, Tan TW, Zhang WWdoaj 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed b
European Heart Journal, 2018 V. Aboyans, Jean-Baptiste Ricco, Marie-Louise Bartelink, Martin Björck, M. Brodmann, T. Cohnert, Jean-Philippe Collet, Martin Czerny, Marco De Carlo, Sebastian Debus, Christine Espinola-Klein, Thomas Kahan, Serge Kownator, Lucia Mazzolai, A. R. Naylor, M. Roffi, Joachim Röther, M. Sprynger, M. Tendera, Gunnar Tepe, M. Venermo, C. Vlachopoulos, I. Desormais, Petr Widimsky, Philippe Kolh, S. Agewall, Héctor Bueno, Antonio Coca, G. D. de Borst, V. Delgado, Florian Dick, Çetin Erol, Marc Ferrini, S. Kakkos, H. Katus, J. Knuuti, J. Lindholt, Heinrich P. Mattle, P. Pienia̧žek, M. Piepoli, Dierk Scheinert, Horst Sievert, Iain A Simpson, Jakub Sulženko, J. Tamargo, L. Tokgozoglu, A. Torbicki, N. Tsakountakis, J. Tuñón, M. D. de Céniga, Stephan Windecker, J. Zamorano, Emanuele Barbato, I. Coman, V. Dean, Donna Fitzsimons, O. Gaemperli, Gerhard Hindricks, Bernard Iung, P. Juni, Patrizio Lancellotti, Christophe Leclercq, Theresa A McDonagh, P. Ponikowski, D. Richter, E. Shlyakhto, Iain A Simpson, P. Zelveian, Markus Haumer, Dzmitry Isachkin, Tine De Backer, M. Dilić, Ivo Petrov, M. V. Kirhmajer, D. Karetova, E. Prescott, Hamdy Soliman, Ants Paapstel, Kimmo Makinen, Slavco Tosev, E. Messas, Zurab Pagava, Oliver J. Müller, K. Naka, Z. Járai, T. Gudjonsson, Michael Jonas, Salvatore Novo, P. Ibrahimi, O. Lunegova, V. Dzērve, Nerijus Misonis, Jean Beissel, E. Pllaha, Mustapha Taberkant, T. Bakken, R. Teles, D. Lighezan, A. Konradi, M. Zavatta, J. Madaric, Z. Fras, L. S. Melchor, Ulf Näslund, Beatrice R. Amann‐Vesti, Agu Obiekezie +105 moresemanticscholar +1 more sourceTargeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization
Advanced Science, EarlyView.This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao +11 morewiley +1 more sourceSleep apnoea is associated with major cardiac events in peripheral arterial disease [PDF]
, 2014 Karri Utriainen, Juhani Airaksinen, Olli Polo, Ruut Laitio, Mikko Pietilä, Harry Scheinin, Tero Vahlberg, Kari Leino, Erkki Kentala, J. Jalonen, Harri Hakovirta, Riitta Parkkola, Sami Virtanen, Timo Laitio +13 moreopenalex +1 more sourceA variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Nature, 2008 T. Thorgeirsson, F. Geller, P. Sulem, T. Rafnar, Anna K. Wiste, K. Magnússon, A. Manolescu, G. Thorleifsson, H. Stefánsson, A. Ingason, S. Stacey, J. Bergthórsson, S. Thorlacius, J. Gudmundsson, Thorlákur Jónsson, Margret Jakobsdottir, J. Saemundsdottir, O. Olafsdottir, L. Gudmundsson, G. Bjornsdottir, K. Kristjánsson, H. Skuladottir, H. Isaksson, T. Gudbjartsson, Gregory T. Jones, T. Mueller, A. Gottsäter, A. Flex, K. Aben, F. Vegt, P. Mulders, D. Isla, M. Vidal, L. Asín, B. Saez, L. Murillo, T. Blondal, H. Kolbeinsson, J. Stefánsson, I. Hansdottir, V. Runarsdottir, R. Pola, B. Lindblad, A. V. Rij, B. Dieplinger, M. Haltmayer, J. Mayordomo, L. Kiemeney, Stefán E. Matthíasson, H. Oskarsson, Thorarinn Tyrfingsson, D. Gudbjartsson, J. Gulcher, S. Jonsson, U. Thorsteinsdóttir, A. Kong, K. Stefánsson +56 moresemanticscholar +1 more sourceSingle‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys
Advanced Science, EarlyView.Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si +10 morewiley +1 more source
