Results 11 to 20 of about 33,898 (192)

Application value of contrast‐enhanced ultrasound in preoperative localization of microwave ablation for primary hyperparathyroidism

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Background Ultrasonography (US) and 99mTechnetium‐sestamibi scintigraphy (99mTc‐MIBI) are currently first‐line imaging modalities to localize parathyroid adenomas with sensitivities of 80% and 84%, respectively. Therefore, finding other modalities to further improve the diagnostic accuracy for preoperative localization is critically needed ...
Fangyi Liu, Li Zang, Yunlin Li, Zhiwei Guan, Yang Liu, Xiaoling Yu, Zhiyu Han, Ping Liang   +7 more
wiley   +1 more source

Tumor budding may be a promising prognostic indicator in intrahepatic cholangiocarcinoma: A multicenter retrospective study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 138-146, January 2023., 2023
High tumor budding is a new candidate for an additional determinant of the T category in staging ICC. An LCSGJ staging system containing an additional evaluation of tumor budding may lead to improved staging accuracy. Abstract Purpose This retrospective study evaluated our hypothesis that high tumor budding (≥10 buds) may help determine the appropriate
Hisashi Kosaka, Mitsuaki Ishida, Masaki Ueno, Koji Komeda, Daisuke Hokutou, Hiroya Iida, Fumitoshi Hirokawa, Kosuke Matsui, Mitsugu Sekimoto, Masaki Kaibori   +9 more
wiley   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

Prediction of need for bowel resection in acute superior mesenteric artery occlusion: A retrospective study of 48 Japanese patients

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 175-181, January 2023., 2023
In a study of 48 patients with acute superior mesenteric artery occlusion, a logistic regression model using time from onset to diagnosis and the occlusion site of superior mesenteric artery showed 78.6% sensitivity in ruling out cases requiring bowel resection.
Susumu Watada, Hideaki Obara, Jun Okui, Kyosuke Hosokawa, Kentaro Matsubara, Hirohisa Harada, Naoki Fujimura, Taku Fujii, Tatsuya Shimogawara, Yuko Kitagawa   +9 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Incidence of and Risk of Mortality After Hip Fractures in Rheumatoid Arthritis Relative to the General Population

Arthritis Care &Research, EarlyView.
Objective Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking.
C. Allyson Jones, Pierre Guy, Hui Xie, Eric C. Sayre, Kai Zhao, Diane Lacaille   +5 more
wiley   +1 more source

Bruton tyrosine kinase inhibitors in the management of Waldenström macroglobulinemia

American Journal of Hematology, Volume 98, Issue 2, Page 338-347, February 2023., 2023
Abstract Bruton tyrosine kinase (BTK) inhibitors have taken a central role in the management of patients with Waldenström macroglobulinemia and are the only agents approved by the Food and Drug Administration (FDA) to treat these patients. Although associated with high rates of durable responses, unmet needs with BTK inhibitor therapy include ...
Jorge J. Castillo, Christian Buske, Judith Trotman, Shayna Sarosiek, Steven P. Treon   +4 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Ischemic Myocardium Targeting Peptide‐Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Nanobubbles functionalized with indocyanine green and ischemic myocardium‐targeting peptide effectively target cardiomyocytes and enable the multimodal (fluorescence, ultrasonic, and photoacoustic) imaging of ischemic myocardium in mice with coronary microvascular dysfunction (CMD).
Bo Yu, Ziwei Pang, Jing Zhao, Jingyi Xue, Hsuan Lo, Tiancheng Gu, Ping Zhang, Jiawei Tian, Guo‐Qing Du   +8 more
wiley   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source